Accession
MI0000814
Symbol
HGNC:
MIR338
Description
Homo sapiens
hsa-mir-338 precursor miRNA mir-338
Gene
family?
family?
RF00686;
mir-338
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR338 is a microRNA implicated in the regulation of osteoblast lineage priming in bone marrow stromal cells, as single-cell transcriptomic analysis has shown that the ablation of MIR338 can restore this priming ability [PMC9898552]. This finding was further supported by evidence from a conditional knockdown of the MIR338 cluster specifically in the preosteoblast lineage, confirming its role in osteogenesis [PMC9898552]. Additionally, MIR338 has been studied for its diagnostic potential in hepatocellular carcinoma (HCC), with a comprehensive search for related studies conducted across multiple databases up to December 15, 2016 [PMC5783480]. This search was aimed at evaluating the diagnostic value of miR-338-5p, a specific variant of MIR338, by reviewing studies from databases such as GEO, PubMed, Embase, Cochrane Library, Web of Science, Sinomed, Chinese VIP database, Wanfang database and China National Knowledge Infrastructure (CNKI) [PMC5783480].
Literature search
96 open access papers mention hsa-mir-338
(715 sentences)
(715 sentences)
Sequence
65923
reads,
385
reads per million, 148 experiments
ucuccAACAAUAUCCUGGUGCUGAGUGaugacucaggcgacUCCAGCAUCAGUGAUUUUGUUGaaga
(((.((((((.(((((((((((((((.............))).))))))))).))).)))))).)))
(((.((((((.(((((((((((((((.............))).))))))))).))).)))))).)))
Structure
c U - - Gauga ucu cAACAA AUC CUGGUGCUG AGU c ||| |||||| ||| ||||||||| ||| u aga GUUGUU UAG GACUACGAC Uca c a U U C gcgga
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr17: 81125883-81125949 [-]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-338
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-338 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-338-5p
| Accession | MIMAT0004701 |
| Description | Homo sapiens hsa-miR-338-5p mature miRNA |
| Sequence | 6 - AACAAUAUCCUGGUGCUGAGUG - 27 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-338-3p
| Accession | MIMAT0000763 |
| Description | Homo sapiens hsa-miR-338-3p mature miRNA |
| Sequence | 42 - UCCAGCAUCAGUGAUUUUGUUG - 63 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
|
