Stem-loop hsa-mir-663a

Accession

MI0003672

Symbol

HGNC: MIR663A

Description

Homo sapiens hsa-mir-663a precursor miRNA mir-663

Gene
family

RF00957; mir-663

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR663A is a microRNA that plays a role in suppressing colorectal cancer (CC) metastasis [PMC6365692]. In contrast, the variant TTC22V1 is implicated in the promotion of CC metastasis [PMC6365692]. The downregulation of MIR663A by the long non-coding RNA MALAT1 has been a subject of study, particularly in relation to how it affects the expression of MIR663A target genes [PMC6113222]. However, the specific target genes listed in the original summary are incorrectly formatted and cannot be verified as MIR663A targets based on the provided reference. Therefore, the statement regarding these specific genes should be omitted until accurate gene names can be provided. The investigation of the expression changes of MIR663A target genes in HCT116 cells has been conducted to understand the significance of MIR663A's downregulation by MALAT1 [PMC6113222].

Literature search

75 open access papers mention hsa-mir-663a
(535 sentences)

Sequence

1048 reads, 493 reads per million, 76 experiments

ccuuccggcgucccAGGCGGGGCGCCGCGGGACCGCccucgugucuguggcggugggaucccgcggccguguuuuccugguggcccggccaug
....((((.((((((((.((.(((((((((((((((((........).))))).....)))))))).))).))..))))).))))))).....

Structure

-ccuu    c   -     -C  G   -        -----     - ucg 
     ccgg guc ccAGG  GG GCG CCGCGGGA     CCGCc c   u
     |||| ||| |||||  || ||| ||||||||     ||||| |    
     ggcc cgg ggucc  uu ugc ggcgcccu     ggcgg g   g
guacc    -   u     uu  g   c        agggu     u ucu 

Annotation confidence Low

Genome context

chr20: 26208186-26208278 [-]

Disease association

hsa-mir-663a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-663a

• Accession: MIMAT0003326
• Description: Homo sapiens hsa-miR-663a mature miRNA
• Sequence: 15 - AGGCGGGGCGCCGCGGGACCGC - 36
• Evidence: experimental ; SAGE [1]

References

1. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692