Stem-loop hsa-mir-20b

Accession

MI0001519

Symbol

HGNC: MIR20B

Description

Homo sapiens hsa-mir-20b precursor miRNA mir-17

Gene
family

RF00051; mir-17

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR20B is a microRNA that has been observed to have low expression in PC3 glioblastoma stem-like cells (GSCs) in comparison to PC1 and PC2 GSCs, indicating a potential role in glioblastoma cell differentiation or maintenance [PMC7463503]. In esophageal cancer cell lines, MIR20B transfection has been shown to influence autophagy, as evidenced by changes in autophagy markers LC3 and p62 [PMC5302951]. Furthermore, MIR20B is part of the miR‐106a‐363 cluster and its overexpression has demonstrated an anti-proliferative effect on cancer cells [PMC8410538]. In the context of breast cancer, upregulation of MIR20B has been associated with reduced metastasis to the lung, suggesting its function as a tumor suppressor miRNA [PMC7062679]. Additionally, genetic variations such as the rs13897515 polymorphism in the MIR20B gene have been linked with differences in amyloid beta levels in cerebrospinal fluid (CSF), which could have implications for Alzheimer's disease (AD) research [PMC9792503]. In individuals without the APOE ε4 allele, higher levels of MIR20B are correlated with a decreased likelihood of AD and an increased likelihood of no cognitive impairment (NCI) [PMC9054681].

Literature search

208 open access papers mention hsa-mir-20b
(659 sentences)

Sequence

12866 reads, 152 reads per million, 136 experiments

aguacCAAAGUGCUCAUAGUGCAGGUAGuuuuggcaugacucuACUGUAGUAUGGGCACUUCCAGuacu
(((((..(((((((((((.(((((..((((.......))))...))))).)))))))))))...)))))

Structure

     -CA           G     -GU    uu 
aguac   AAGUGCUCAUA UGCAG   AGuu  g
|||||   ||||||||||| |||||   ||||  g
ucauG   UUCACGGGUAU AUGUC   ucag  c
     ACC           G     Auc    ua 

Annotation confidence High

Genome context

chrX: 134169809-134169877 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-20b

Disease association

hsa-mir-20b is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-20b is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-20b is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-20b-5p

• Accession: MIMAT0001413
• Description: Homo sapiens hsa-miR-20b-5p mature miRNA
• Sequence: 6 - CAAAGUGCUCAUAGUGCAGGUAG - 28
• Evidence: experimental ; array-cloned [2], cloned [3-5]

Mature hsa-miR-20b-3p

• Accession: MIMAT0004752
• Description: Homo sapiens hsa-miR-20b-3p mature miRNA
• Sequence: 44 - ACUGUAGUAUGGGCACUUCCAG - 65
• Evidence: experimental ; cloned [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


5. PubMed ID: 15944709
   c-Myc-regulated microRNAs modulate E2F1 expression
   "O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT"
   "Nature (2005) 435:839-843