Accession
MI0000489
Symbol
HGNC:
MIR195
Description
Homo sapiens
hsa-mir-195 precursor miRNA mir-15
Gene
family?
family?
RF00455;
mir-15
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-195 is a microRNA implicated in various cellular processes, including those relevant to cancer biology [PMC5706292]. In a study using MCF-7 cells, a model for breast cancer, cells transfected with hsa-mir-195 showed a notable reduction in cytosolic lipid droplets compared to those transfected with a non-specific scrambled control [PMC4668367]. However, the overexpression of hsa-mir-195 did not significantly alter the mRNA levels of CYP27B1, an enzyme involved in vitamin D metabolism [PMC4668367]. In contrast, the inhibition of hsa-mir-195 using antimiR-195 resulted in an increase of CYP27B1 mRNA by 1.6-fold [PMC4668367]. These findings indicate that while hsa-mir-195 has potential anti-cancer effects, its therapeutic efficacy may be compromised by cellular mechanisms that excrete or otherwise neutralize it [PMC5706292]. Therefore, any therapeutic strategies involving hsa-mir-195 should account for the possibility that cancer cells may evade its effects by actively removing it from the cell [PMC5706292].
Literature search
231 open access papers mention hsa-mir-195
(1860 sentences)
(1860 sentences)
Sequence
191769
reads,
1198
reads per million, 153 experiments
agcuucccuggcucUAGCAGCACAGAAAUAUUGGCacagggaagcgagucugCCAAUAUUGGCUGUGCUGCUCCaggcaggguggug
.(((.(((((.((..((((((((((.((((((((((..((........))))))))))))..))))))))))..)).))))).))).
.(((.(((((.((..((((((((((.((((((((((..((........))))))))))))..))))))))))..)).))))).))).
Structure
a u g cU -A ca gaa gcu cccug cu AGCAGCACAG AAUAUUGGCa gg g ||| ||||| || |||||||||| |||||||||| || ugg gggac ga UCGUCGUGUC UUAUAACCgu cu c g u g CC GG -- gag
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].
Genome context
chr17: 7017615-7017701 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-195
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-195 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-195-5p
| Accession | MIMAT0000461 |
| Description | Homo sapiens hsa-miR-195-5p mature miRNA |
| Sequence | 15 - UAGCAGCACAGAAAUAUUGGC - 35 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-195-3p
| Accession | MIMAT0004615 |
| Description | Homo sapiens hsa-miR-195-3p mature miRNA |
| Sequence | 53 - CCAAUAUUGGCUGUGCUGCUCC - 74 |
| Evidence |
experimental
cloned [2] |
References
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