Accession
MI0000440
Symbol
HGNC:
MIR27B
Description
Homo sapiens
hsa-mir-27b precursor miRNA mir-27
Gene
family?
family?
RF00644;
mir-27
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR27B is a microRNA implicated in various biological processes and diseases, including its role as a key inhibitor in thymic involution, as suggested by its interaction with Wnt4 [PMC5933288]. This microRNA has also been observed to be involved in breast cancer progression, where its reduction, induced by CCL18, enhances invasion and migration in cancer cell lines [PMC4653020]. In the context of temporal lobe epilepsy (TLE), MIR27B is part of a chromosomal cluster on chromosome 9 that is hypermethylated compared to controls [PMC9700089]. Furthermore, MIR27B has been identified as a regulator of VEGFC expression and has been associated with the suppression of tumor growth and metastasis in various cancers including gastric cancer, bladder cancer, and hepatocellular carcinoma [PMC7780026]. Lastly, MIR27B may have a role in the regulation of HIV-1 transcription according to recent research findings [PMC3697138].
Literature search
301 open access papers mention hsa-mir-27b
(1259 sentences)
(1259 sentences)
Sequence
882609
reads,
4618
reads per million, 159 experiments
accucucuaacaaggugcAGAGCUUAGCUGAUUGGUGAACagugauugguuuccgcuuugUUCACAGUGGCUAAGUUCUGCaccugaagagaaggug
((((((((....(((((((((((((((((.((((.(((((((....(((...)))..))))))))))))))))))))))))))))..)))).)))).
((((((((....(((((((((((((((((.((((.(((((((....(((...)))..))))))))))))))))))))))))))))..)))).)))).
Structure
- - aaca G G ugau u accu cucu aggugcAGAGCUUAGCU AUUG UGAACag ugg |||| |||| ||||||||||||||||| |||| ||||||| ||| u ugga gaga uccaCGUCUUGAAUCGG UGAC ACUUguu gcc g a --ag - - --uc u
Annotation confidence
High
Do you think this miRNA is real?
Comments
Lagos-Quintana et al. determined the expression of miR-27b in mouse [1] - a human sequence was predicted based on homology. Michael et al. subsequently verified the expression of this miRNA in human cells [2].
Genome context
chr9: 95085445-95085541 [+]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-27b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-27b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-27b-5p
| Accession | MIMAT0004588 |
| Description | Homo sapiens hsa-miR-27b-5p mature miRNA |
| Sequence | 19 - AGAGCUUAGCUGAUUGGUGAAC - 40 |
| Evidence |
experimental
cloned [4-5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-27b-3p
| Accession | MIMAT0000419 |
| Description | Homo sapiens hsa-miR-27b-3p mature miRNA |
| Sequence | 61 - UUCACAGUGGCUAAGUUCUGC - 81 |
| Evidence |
experimental
cloned [2-5] |
| Database links |
|
| Predicted targets |
|
References
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