Stem-loop hsa-mir-15b

Accession

MI0000438

Symbol

HGNC: MIR15B

Description

Homo sapiens hsa-mir-15b precursor miRNA mir-15

Gene
family

RF00455; mir-15

Literature search

405 open access papers mention hsa-mir-15b
(1510 sentences)

Sequence

476877 reads, 5285 reads per million, 129 experiments

uugaggccuuaaaguacugUAGCAGCACAUCAUGGUUUACAugcuacagucaagaugCGAAUCAUUAUUUGCUGCUCUAgaaauuuaaggaaauucau
.((((.(((((((...(((.(((((((.((.(((((((.(((.((.......))))).))))))).)).))))))).)))...)))))))...)))).

Structure

u    --g       gua   U       C  C       A   g  ac 
 ugag   ccuuaaa   cug AGCAGCA AU AUGGUUU CAu cu  a
 ||||   |||||||   ||| ||||||| || ||||||| ||| ||  g
 acuu   ggaauuu   gAU UCGUCGU UA UACUAAG gua ga  u
u    aaa       aaa   C       U  U       C   -  ac 

Annotation confidence High

Comments

This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-15b in human [2].

Genome context

chr3: 160404588-160404685 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-15b

Disease association

hsa-mir-15b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-15b-5p

• Accession: MIMAT0000417
• Description: Homo sapiens hsa-miR-15b-5p mature miRNA
• Sequence: 20 - UAGCAGCACAUCAUGGUUUACA - 41
• Evidence: experimental ; cloned [2-5]

Mature hsa-miR-15b-3p

• Accession: MIMAT0004586
• Description: Homo sapiens hsa-miR-15b-3p mature miRNA
• Sequence: 58 - CGAAUCAUUAUUUGCUGCUCUA - 79
• Evidence: experimental ; cloned [4-5]

References

1. PubMed ID: 12554860
   Numerous microRNPs in neuronal cells containing novel microRNAs
   "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
   "RNA (2003) 9:180-186


2. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


3. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


4. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


5. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739