Accession
MI0000301
Symbol
HGNC:
MIR224
Description
Homo sapiens
hsa-mir-224 precursor miRNA mir-224
Gene
family?
family?
RF00680;
mir-224
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR224 is a microRNA that plays a significant role in various biological processes and has been linked to diseases such as cancer and autoimmune disorders [PMC5351619]. Its expression increases when Cx43 is reduced in siAQP4 treated animals, suggesting a regulatory relationship [PMC5843607]. Estradiol is a crucial regulator of MIR224, which has implications for esophageal adenocarcinoma and esophageal squamous cell carcinoma [PMC6609598]. MIR224 is also considered a potential biomarker for esophageal adenocarcinoma, as indicated by its association with the disease [PMC6609598]. In pancreatic adenocarcinoma, MIR224 is involved in disease progression, and in ovarian cancer, it contributes to chemoresistance by affecting the PRKCD pathway [PMC6005310; PMC8071157].. In colorectal cancer, MIR224 targets genes such as glycine methyltransferases and is involved in the epithelial-mesenchymal transition by interacting with the Smad7/TGFβ pathway [PMC9775527; PMC5240405].. It has been identified as an overexpressed prognostic marker in colorectal cancer and WNT medulloblastomas [PMC5935085; PMC4333163].. MIR224's interaction with Smad4 and HOXD10 promotes cell migration in hepatocellular carcinoma and colorectal cancer, and it also regulates natural killer cell function by modulating NCR1 transcript levels [PMC5226496; PMC9166526].. Dysregulation of MIR224 is linked to the loss of cell cycle control in hepatocellular carcinoma and to changes in angiogenesis following a stroke [PMC6271763; PMC6732937]..
Literature search
123 open access papers mention hsa-mir-224
(843 sentences)
(843 sentences)
Sequence
19600
reads,
734
reads per million, 116 experiments
gggcuuUCAAGUCACUAGUGGUUCCGUUUAGuagaugauugugcauuguuucAAAAUGGUGCCCUAGUGACUACAaagccc
(((((((..(((((((((.(((.((((((.(.(((((((.....)))))))).)))))).))))))))))))..)))))))
(((((((..(((((((((.(((.((((((.(.(((((((.....)))))))).)))))).))))))))))))..)))))))
Structure
CA U U A u u
gggcuuU AGUCACUAG GGU CCGUUU G agaugau g
||||||| ||||||||| ||| |||||| | ||||||| u
cccgaaA UCAGUGAUC CCG GGUAAA c uuuguua g
CA - U A - c
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 151958578-151958658 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-224
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-224 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-224 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-224 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-224-5p
| Accession | MIMAT0000281 |
| Description | Homo sapiens hsa-miR-224-5p mature miRNA |
| Sequence | 7 - UCAAGUCACUAGUGGUUCCGUUUAG - 31 |
| Evidence |
experimental
cloned [1-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-224-3p
| Accession | MIMAT0009198 |
| Description | Homo sapiens hsa-miR-224-3p mature miRNA |
| Sequence | 53 - AAAAUGGUGCCCUAGUGACUACA - 75 |
| Evidence |
experimental
qRT-PCR [5], 454 [6] |
| Database links |
|
| Predicted targets |
|
References
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