Accession
MI0000294
Symbol
HGNC:
MIR218-1
Description
Homo sapiens
hsa-mir-218-1 precursor miRNA mir-218
Gene
family?
family?
RF00255;
mir-218
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR218-1 is a microRNA encoded within an intron of the SLIT2 gene, which plays a significant role in various biological processes, including the Wnt signaling pathway and cancer development [PMC5909645]. Overexpression of the Wnt signaling pathway leads to an increase in MIR218-1 levels, which is also reflected in the levels of its precursor form [PMC4748271]. MIR218-1 is implicated in the regulation of CUL3, a gene overexpressed in kidney and prostate cancers, and its expression is downregulated in these cancer types [PMC2683874]. In cardiovascular disease, MIR218-1 expression was consistently reduced across all four grades of diseased valve datasets [PMC7197751]. Furthermore, it was one of only three transcripts differentially expressed across all grades within these datasets [PMC7197751]. In cancer research, MIR218-1 has been shown to influence tumor angiogenesis and cell migration and invasion, highlighting its significant impact on cancer cell fate [PMC6712160]. Additionally, it has been found to be upregulated in stenotic colon segments when compared to normal colon tissue [PMC4774952], indicating its potential role in gastrointestinal diseases. The regulation of MIR218-1 can occur independently from its host gene SLIT2 as seen both in human and zebrafish studies [PMC6523689], suggesting a complex regulatory mechanism.
Literature search
177 open access papers mention hsa-mir-218-1
(1072 sentences)
(1072 sentences)
Sequence
207527
reads,
1697
reads per million, 133 experiments
gugauaauguagcgagauuuucugUUGUGCUUGAUCUAACCAUGUgguugcgagguaugaguaaaacAUGGUUCCGUCAAGCACCAUGGaacgucacgcagcuuucuaca
(((..((.((.(((.(((.((((((.(((((((((..((((((((..((((.........)))).))))))))..))))))))).)))))).))).))).))))..))).
(((..((.((.(((.(((.((((((.(((((((((..((((((((..((((.........)))).))))))))..))))))))).)))))).))).))).))))..))).
Structure
- au u a a u U CU gg gag gug aa gu gcg gau uucugU GUGCUUGAU AACCAUGU uugc g ||| || || ||| ||| |||||| ||||||||| |||||||| |||| u cau uu cg cgc cug aaGGUA CACGAACUG UUGGUAca aaug a a cu - a a c C CC -a agu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. later verified the expression of miR-218 in human [2].
Genome context
chr4: 20528275-20528384 [+]
Disease association
hsa-mir-218-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-218-5p
| Accession | MIMAT0000275 |
| Description | Homo sapiens hsa-miR-218-5p mature miRNA |
| Sequence | 25 - UUGUGCUUGAUCUAACCAUGU - 45 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-218-1-3p
| Accession | MIMAT0004565 |
| Description | Homo sapiens hsa-miR-218-1-3p mature miRNA |
| Sequence | 68 - AUGGUUCCGUCAAGCACCAUGG - 89 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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