miRBase entry: hsa-mir-18a

Stem-loop hsa-mir-18a

Homo sapiens hsa-mir-18a precursor miRNA
Gene family
MIPF0000001; mir-17

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR18A is an oncogenic microRNA that is expressed in glioma cells. Its expression increases with both matrix stiffness and fibronectin concentration [PMC5876527]. Within the miR19-72 cluster, miR17, miR19a, and miR20a have higher levels of mature miRNA compared to MIR18A, miR19b, and miR92a [PMC9322280].

Literature search
274 open access papers mention hsa-mir-18a
(833 sentences)


630386 reads, 8032 reads per million, 124 experiments

    cU    U    C   U    A   -  aa u 
uguu  AAGG GCAU UAG GCAG UAG ug  g a
||||  |||| |||| ||| |||| ||| ||  | g
acGG  UUCC CGUG AUC CGUC Auc ac  u a
    UC    U    A   C    -   u  ga u 

Annotation confidence High
Do you think this miRNA is real?
This sequence maps to chromosome 13 and is named miR-18 precursor-13 in reference [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].

Genome context
chr13: 91350751-91350821 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-18a
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-18a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-18a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-18a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-18a-5p

Accession MIMAT0000072
Description Homo sapiens hsa-miR-18a-5p mature miRNA
Evidence experimental
cloned [1,3-6], Northern [1]
Database links
Predicted targets

Mature hsa-miR-18a-3p

Accession MIMAT0002891
Description Homo sapiens hsa-miR-18a-3p mature miRNA
Evidence experimental
cloned [4-6]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728

  6. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854