Accession
MI0000072
Symbol
HGNC:
MIR18A
Description
Homo sapiens
hsa-mir-18a precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR18A is an oncogenic microRNA whose expression is influenced by the biomechanical properties of the cellular environment in glioma cells [PMC5876527]. Specifically, studies have demonstrated that an increase in matrix stiffness, as well as a higher concentration of fibronectin, correlates with elevated levels of MIR18A expression [PMC5876527]. However, the provided context does not offer information regarding the expression levels of MIR18A within the miR-17-92 cluster or its comparison to miR17, miR19a, and miR20a, and thus no conclusions can be drawn about its relative expression within this cluster [PMC9322280].
Literature search
274 open access papers mention hsa-mir-18a
(833 sentences)
(833 sentences)
Sequence
630386
reads,
8032
reads per million, 124 experiments
uguucUAAGGUGCAUCUAGUGCAGAUAGugaaguagauuagcaucuACUGCCCUAAGUGCUCCUUCUGGca
((((..((((.((((.(((.((((.(((((..(.....)..)).))))))).))).)))).))))..))))
((((..((((.((((.(((.((((.(((((..(.....)..)).))))))).))).)))).))))..))))
Structure
cU U C U A - aa u
uguu AAGG GCAU UAG GCAG UAG ug g a
|||| |||| |||| ||| |||| ||| || | g
acGG UUCC CGUG AUC CGUC Auc ac u a
UC U A C - u ga u
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence maps to chromosome 13 and is named miR-18 precursor-13 in reference [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].
Genome context
chr13: 91350751-91350821 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-18a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-18a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-18a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-18a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-18a-5p
| Accession | MIMAT0000072 |
| Description | Homo sapiens hsa-miR-18a-5p mature miRNA |
| Sequence | 6 - UAAGGUGCAUCUAGUGCAGAUAG - 28 |
| Evidence |
experimental
cloned [1,3-6], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-18a-3p
| Accession | MIMAT0002891 |
| Description | Homo sapiens hsa-miR-18a-3p mature miRNA |
| Sequence | 47 - ACUGCCCUAAGUGCUCCUUCUGG - 69 |
| Evidence |
experimental
cloned [4-6] |
| Database links |
|
| Predicted targets |
|
References
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