Stem-loop sequence hsa-mir-194-1

Accession

MI0000488 (change log)

Previous IDs

hsa-mir-194

Symbol

HGNC:MIR194-1

Description

Homo sapiens miR-194-1 stem-loop

Gene family

MIPF0000055; mir-194

Literature search

143 open access papers mention hsa-mir-194-1
(1005 sentences)

Stem-loop

   a    - uu      u         a      g    cu  gu 
5'  uggu g  aucaag guaacagca cuccau ugga  gu  a
    |||| |  |||||| ||||||||| |||||| ||||  ||   
3'  acca u  uaguuu cauugucgu gaggug accu  ua  c
   a    u gg      u         a      -    -u  ac 

Deep sequencing

109326 reads, 168 reads per million, 154 experiments

Confidence

Annotation confidence: not enough data

Feedback: Do you believe this miRNA is real?

Comments

This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-194 in human [2]. Two putative pairs of orthologous hairpin precursors structures are found in mouse (mir-194-1 (MI0000236) on chromosome 1, and mir-194-2 (MI0000733) on chromosome 19) and human (mir-194-1 (MI0000488) on chromosome 1, and mir-194-2 (MI0000732) on chromosome 11).

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr1: 220118157-220118241 [-]
• Overlapping transcripts:

  sense

  OTTHUMT00000098802 ; SLC30A10-002; intron 1

  ENST00000484239 ; SLC30A10-002; intron 1

  ENST00000536446 ; SLC30A10-201; intron 1

Clustered miRNAs

< 10kb from hsa-mir-194-1

• hsa-mir-194-1: chr1: 220118157-220118241 [-]
• hsa-mir-215: chr1: 220117853-220117962 [-]

Database links

• EntrezGene:MIR194-1
• HGNC:MIR194-1
• RNAcentral:URS00002D5B50_9606
• miRBase Tracker:MI0000488

Mature sequence hsa-miR-194-5p

• Accession: MIMAT0000460
• Previous IDs: hsa-miR-194
• Sequence: 15 - uguaacagcaacuccaugugga - 36
• Deep sequencing: 215327 reads, 154 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS000029C2DC_9606
• Predicted targets:
  • TargetMiner:hsa-miR-194-5p
  • TargetScanVert:hsa-miR-194-5p
  • miRDB:hsa-miR-194-5p
  • microrna.org:hsa-miR-194-5p

References

1. PMID:12554859 "New microRNAs from mouse and human" Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T RNA. 9:175-179(2003).
2. PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).