Accession
MI0000732
Symbol
HGNC:
MIR194-2
Description
Homo sapiens
hsa-mir-194-2 precursor miRNA mir-194
Gene
family?
family?
RF00257;
mir-194
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR194-2 is a miRNA cluster located on chromosome 11q13.1 [PMC6120784]. It is part of the MIR192-194-2 cluster, which has been reported to respond to p53 activation [PMC6120784]. MIR194-1 and MIR194-2, although located on different chromosomes, share an identical mature sequence and target the same type of mRNAs [PMC6120784]. The methylation levels at MIR194-2 were observed using the Mann-Whitney test to compare squamous and Barrett's groups [PMC6120784]. The coexpression of MIR192 and MIR194-2 in Barrett's esophagus (BE) was investigated in relation to genomic and epigenetic alterations [PMC6120784]. In a study on miRNA expression signatures, MIR194-2 was among the top-ranked miRNAs [PMC9284388]. It has also been found to be upregulated in lung cancer and downregulated in epilepsy patients, suggesting its potential as a diagnostic biomarker for these conditions [PMC3143163] [PMC7465068]. Additionally, an SNP in MIR194-2 was shown to be differentially expressed in lung cancer [PMC3143163]. The upregulation of miR194-1 and MIR194-2 demonstrated good diagnostic performance for certain conditions, with AUROC values of 0.946 and 0.940, respectively [PMC6005310]. In patients with focal cortical dysplasia (FCD), exosomal miRNAs including MIR194-2 were found to be upregulated in circulating serum exosomes [PMC7465068]. Overall, these findings highlight the potential role of MIR194-2 as a biomarker for various diseases.
Literature search
142 open access papers mention hsa-mir-194-2
(1015 sentences)
(1015 sentences)
Sequence
60146
reads,
297
reads per million, 148 experiments
ugguucccgcccccUGUAACAGCAACUCCAUGUGGAagugcccacugguuCCAGUGGGGCUGCUGUUAUCUGgggcgagggccag
((((((.((((((..(((((((((.((((((.((((...(((....))))))))))))).)))))))))..)))))).)))))).
((((((.((((((..(((((((((.((((((.((((...(((....))))))))))))).)))))))))..)))))).)))))).
Structure
- c cU A G agu c ugguuc cgcccc GUAACAGCA CUCCAU UGGA gcc a |||||| |||||| ||||||||| |||||| |||| ||| accggg gcgggG UAUUGUCGU GGGGUG ACCu ugg c g a UC C - --- u
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-194 in human [2]. Two putative pairs of orthologous hairpin precursors structures are found in mouse (mir-194-1 (MIR:MI0000236) on chromosome 1, and mir-194-2 (MIR:MI0000733) on chromosome 19) and human (mir-194-1 (MIR:MI0000488) on chromosome 1, and mir-194-2 (MIR:MI0000732) on chromosome 11).
Genome context
chr11: 64891355-64891439 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-194-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-194-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-194-5p
| Accession | MIMAT0000460 |
| Description | Homo sapiens hsa-miR-194-5p mature miRNA |
| Sequence | 15 - UGUAACAGCAACUCCAUGUGGA - 36 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-194-3p
| Accession | MIMAT0004671 |
| Description | Homo sapiens hsa-miR-194-3p mature miRNA |
| Sequence | 51 - CCAGUGGGGCUGCUGUUAUCUG - 72 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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