Stem-loop sequence hsa-mir-106a

Accession

MI0000113 (change log)

Previous IDs

hsa-mir-106-X;hsa-mir-106

Symbol

HGNC:MIR106A

Description

Homo sapiens miR-106a stem-loop

Gene family

MIPF0000001; mir-17

Literature search

256 open access papers mention hsa-mir-106a
(955 sentences)

Stem-loop

     u   cc      -           g     g   c  u 
5' cc ugg  auguaa aagugcuuaca ugcag uag uu u
   || |||  |||||| ||||||||||| ||||| ||| || u
3' gg acc  uacauu uucacgaaugu acguc auc ag g
     u   au      c           a     -   u  a 

Deep sequencing

2193706 reads, 7.94e+03 reads per million, 159 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This miRNA was not cloned in reference [1], rather it was identified by homology to miR-91 (MI0000071). This sequence is localised to chromosome X and was named mir-106-X in [1]. Mouse and human miR-106a (MI0000406 and MI0000113) differ at two positions but the precursor sequences are clearly closely related. The sequences are also related to mir-17 (MI0000071 and MI0000687). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chrX: 134170198-134170278 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from hsa-mir-106a

• hsa-mir-106a: chrX: 134170198-134170278 [-]
• hsa-mir-18b: chrX: 134170041-134170111 [-]
• hsa-mir-20b: chrX: 134169809-134169877 [-]
• hsa-mir-19b-2: chrX: 134169671-134169766 [-]
• hsa-mir-92a-2: chrX: 134169538-134169612 [-]
• hsa-mir-363: chrX: 134169378-134169452 [-]

Database links

• EntrezGene:MIR106A
• HGNC:MIR106A
• RNAcentral:URS000039E1E1_9606
• Rfam:mir-17
• miRBase Tracker:MI0000113

Mature sequence hsa-miR-106a-5p

• Accession: MIMAT0000103
• Previous IDs: hsa-miR-106a
• Sequence: 13 - aaaagugcuuacagugcagguag - 35
• Deep sequencing: 2188147 reads, 159 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS00003FE4D4_9606
• Predicted targets:
  • TargetMiner:hsa-miR-106a-5p
  • TargetScanVert:hsa-miR-106a-5p
  • miRDB:hsa-miR-106a-5p
  • microrna.org:hsa-miR-106a-5p

Mature sequence hsa-miR-106a-3p

• Accession: MIMAT0004517
• Previous IDs: hsa-miR-106a*
• Sequence: 50 - cugcaauguaagcacuucuuac - 71
• Deep sequencing: 5556 reads, 110 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS00005F5B9E_9606
• Predicted targets:
  • TargetMiner:hsa-miR-106a-3p
  • TargetScanVert:hsa-miR-106a-3p
  • miRDB:hsa-miR-106a-3p
  • microrna.org:hsa-miR-106a-3p

References

1. PMID:11914277 "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G Genes Dev. 16:720-728(2002).
2. PMID:12554860 "Numerous microRNPs in neuronal cells containing novel microRNAs" Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G RNA. 9:180-186(2003).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).