miRBase entry: cel-lin-4

Stem-loop cel-lin-4


Accession
MI0000002
Description
Caenorhabditis elegans cel-lin-4 precursor miRNA
Gene family
MIPF0000303; lin-4

Literature search
49 open access papers mention cel-lin-4
(381 sentences)

Sequence

348252 reads, 2214 reads per million, 15 experiments
augcuuccggccuguUCCCUGAGACCUCAAGUGUGAguguacuauugaugcuucACACCUGGGCUCUCCGGGUACCaggacgguuugagcagau
.((((((((.((((..(((.((((.((((.(((((((.((((....).)))))))))).)))).)))).)))...)))).)))...)))))...

Structure
--a     ---   g    -uU   U    C    A       u   - u 
   ugcuu   ccg ccug   CCC GAGA CUCA GUGUGAg gua c a
   |||||   ||| ||||   ||| |||| |||| ||||||| ||| |  
   acgag   ggc ggaC   GGG CUCU GGGU CACAcuu cgu g u
uag     uuu   a    CAU   C    C    C       -   a u 


Annotation confidence High
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Comments
lin-4 is found on chromosome II in Caenorhabditis elegans [1] and is complementary to sequences in the 3' untranslated region (UTR) of lin-14 mRNA. lin-4 acts to developmentally repress the accumulation of lin-14 protein. This repression is essential for the proper timing of numerous events of Caenorhabditis elegans larval development [2].

Genome context
chrII: 5902254-5902347 [+]

Database links

Mature cel-lin-4-5p

Accession MIMAT0000002
Description Caenorhabditis elegans cel-lin-4-5p mature miRNA
Sequence 16 - UCCCUGAGACCUCAAGUGUGA - 36
Evidence experimental
cloned [1,3-4], 454 [5], Illumina [6], CLIPseq [7]
Database links
Predicted targets

Mature cel-lin-4-3p

Accession MIMAT0015092
Description Caenorhabditis elegans cel-lin-4-3p mature miRNA
Sequence 55 - ACACCUGGGCUCUCCGGGUACC - 76
Evidence experimental
CLIPseq [7]
Database links

References

  1. PubMed ID: 11679671
    An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    "Lau NC, Lim LP, Weinstein EG, Bartel DP"
    "Science (2001) 294:858-862

  2. PubMed ID: 12672692
    The microRNAs of Caenorhabditis elegans
    "Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP"
    "Genes Dev (2003) 17:991-1008

  3. PubMed ID: 12747828
    MicroRNAs and other tiny endogenous RNAs in C. elegans
    "Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D"
    "Curr Biol (2003) 13:807-818

  4. PubMed ID: 17174894
    Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
    "Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H, Bartel DP"
    "Cell (2006) 127:1193-1207

  5. PubMed ID: 19460142
    Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development
    Kato M, de Lencastre A, Pincus Z, Slack FJ
    Genome Biol (2009) 10:R54

  6. PubMed ID: 20062054
    Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
    "Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli AE, Yeo GW"
    "Nat Struct Mol Biol (2010) 17:173-179

  7. PubMed ID: 10642801
    The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    "Olsen PH, Ambros V"
    "Dev Biol (1999) 216:671-680