Accession
MI0016868
Symbol
HGNC:
MIR4505
Description
Homo sapiens
hsa-mir-4505 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
hsa-mir-4505 is a microRNA that has been implicated in various biological processes and diseases. It has been observed to interact with the messenger RNA of HOOK3 and PCP4L1, suggesting a regulatory role in gene expression [PMC9738797]. This microRNA has also been reported to be involved in infectious contexts, indicating its potential role in immune responses [PMC4865051]. In studies of HIV patients, hsa-mir-4505 was found to be downregulated in elite controllers (EC) compared to HIV-negative individuals [PMC4865051]. Additionally, it was ubiquitously downregulated across various patient groups when compared with HIV-negative individuals, suggesting a consistent pattern of expression alteration associated with HIV infection [PMC4865051]. In the context of cardiovascular (CV) events, hsa-mir-4505 was identified as downregulated; however, its specific role in CV risk or disease had not been established at the time of the study [PMC9827273]. Furthermore, hsa-mir-4505 was found to be up-regulated when H5N1 avian influenza virus nonstructural protein 1 (NS1) was expressed in HEK293 cells [PMC6830863], and it is involved in regulating heat shock protein A12B (HSPA12B), exacerbating lipopolysaccharide-induced vascular endothelial cell injury [PMC9436632]. Despite these findings, some studies have not shown significant changes in its expression levels under certain conditions [PMC4416288].
Literature search
2 open access papers mention hsa-mir-4505
(3 sentences)
(3 sentences)
Sequence
19
reads,
4
reads per million, 8 experiments
ggAGGCUGGGCUGGGACGGAcacccggccuccacuuucuguggcagguaccuccuccaugucggcccgccuug
.(((((.(((((((.(.(((......((((((((.....)))).))))......))).).)))))))))))).
.(((((.(((((((.(.(((......((((((((.....)))).))))......))).).)))))))))))).
Structure
g U G C cacccg - u gAGGC GGGCUGG A GGA gccu ccac u ||||| ||||||| | ||| |||| |||| u uuccg cccggcu u ccu ugga ggug c g - g a ccucca c u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr14: 73758747-73758819 [+]
Disease association
hsa-mir-4505 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4505
| Accession | MIMAT0019041 |
| Description | Homo sapiens hsa-miR-4505 mature miRNA |
| Sequence | 3 - AGGCUGGGCUGGGACGGA - 20 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
|
References
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