Stem-loop hsa-mir-4454

Accession

MI0016800

Symbol

HGNC: MIR4454

Description

Homo sapiens hsa-mir-4454 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR4454 is a microRNA that has been identified as overexpressed in ameloblastoma tumors, a type of benign but locally aggressive odontogenic neoplasm [PMC7920560][PMC5354851[PMC5354851]. The overexpression of MIR4454 has been associated with a reduction in tumor tissue and an increased sensitivity to chemotherapeutic agents such as 5FU, CPT11, and oxaliplatin [PMC7602903]. This suggests that MIR4454 may play a role in the cellular response to chemotherapy. Conversely, the downregulation of MIR4454 has been linked to drug resistance in colorectal cancer (CRC), indicating its potential as a therapeutic target for overcoming resistance [PMC7602903]. Additionally, there is evidence that the sequence of some hsa-miR-4454 reads may differ from its annotated genomic locus and instead match the sequence of tRNAHis, which could have implications for its biogenesis and function [PMC6675128]. The expression profile of MIR4454 has also been studied in hepatocellular carcinoma (HCC), further highlighting its relevance in cancer research [PMC7035418].

Literature search

7 open access papers mention hsa-mir-4454
(21 sentences)

Sequence

25232 reads, 349 reads per million, 126 experiments

ccGGAUCCGAGUCACGGCACCAaauuucaugcguguccgugugaagagaccacca
..((.(((....((((((((((.......)).))).)))))....).))))....

Structure

--cc  A  - GAGU     -   -  aa 
    GG UC C    CACGG CAC CA  u
    || || |    ||||| ||| ||  u
    cc ag g    gugcc gug gu  u
acca  -  a aagu     u   c  ac 

Annotation confidence Not enough data

Genome context

chr4: 163093574-163093628 [-]

Disease association

hsa-mir-4454 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4454

• Accession: MIMAT0018976
• Description: Homo sapiens hsa-miR-4454 mature miRNA
• Sequence: 3 - GGAUCCGAGUCACGGCACCA - 22
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127