Stem-loop hsa-mir-4451

Accession

MI0016797

Symbol

HGNC: MIR4451

Description

Homo sapiens hsa-mir-4451 precursor miRNA mir-4451

Gene
family

RF03429; mir-4451

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR4451 is a microRNA that is induced by atRA exposure and is associated with nutrient metabolism [PMC4168020] [PMC6138641]. It has been found to be up-regulated in differently developed seeds of AK58 and in superior and inferior seeds of different developmental stages [PMC6138641]. The expression levels of MIR4451 were decreased from 28 DAF to 42 DAF in SGP [PMC6138641]. MIR4451 targets CM 17, which may modulate nutrient storage in cereal seeds [PMC6138641'>PMC6138641]. The expression levels of MIR4451 were found to be up-regulated from 7 DAF to 21 DAF, with a peak at 21 DAF in SGP [PMC6138641]. The targets containing TC425315 (ARF), TC416811 (NAC), TC426980 (Hox9), TC386518 (VPE1), TC369161 (TFIID), TC370181 (TacaM2), CA733841 (CM17), TC409188 (PRKL), TC415749 (Resistance protein), TC381152, TC432124, and TC385289 showed converse expression profiles when compared with the expression levels of MIR4451 during the same grain-filling periods of superior and inferior grains [PMC6138641].

Sequence

153 reads, 13 reads per million, 26 experiments

ucuguaccucagcuuugcucccaaccaaccacuuccacauguuuugcUGGUAGAGCUGAGGACAgc
.((((.(((((((((((((..(((..(((...........))))))..))))))))))))))))).

Structure

u    a             cc   cc   cacu 
 cugu ccucagcuuugcu  caa  aac    u
 |||| |||||||||||||  |||  |||    c
 gACA GGAGUCGAGAUGG  guu  uug    c
c    -             Uc   --   uaca 

Annotation confidence Not enough data

Genome context

chr4: 85722468-85722533 [+]

Disease association

hsa-mir-4451 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4451

• Accession: MIMAT0018973
• Description: Homo sapiens hsa-miR-4451 mature miRNA
• Sequence: 48 - UGGUAGAGCUGAGGACA - 64
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127