Stem-loop hsa-mir-4443

Accession

MI0016786

Symbol

HGNC: MIR4443

Description

Homo sapiens hsa-mir-4443 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR4443 is a microRNA that has been identified as one of the most highly expressed in non-SC-EVs, suggesting a significant role in extracellular vesicle biology [PMC9800941]. It is associated with a better prognosis in certain conditions, as indicated by a systematic review and meta-analysis [PMC7827149]. Bioinformatics analyses have identified METTL3 as a target gene of MIR4443, implicating it in the regulation of gene expression [PMC9617873]. MIR4443 is also one of the miRNAs that are upregulated and associated with better prognosis, distinguishing it from other miRNAs that are linked to poor prognosis [PMC6830093]. The expression profile of MIR4443 has been assessed using RT-qPCR, highlighting its relevance to hepatocellular carcinoma (HCC) research [PMC7035418]. Although its specificity to Graves' disease (GD) has not been fully explored in other autoimmune diseases, MIR4443's role in GD has been acknowledged [PMC5671953]. Importantly, MIR4443 has been shown to inhibit cisplatin-induced ferroptosis by regulating AIFM2 expression through an m6A-dependent mechanism, suggesting its potential therapeutic implications [PMC8572460].

Literature search

6 open access papers mention hsa-mir-4443
(63 sentences)

Sequence

4003 reads, 1181 reads per million, 80 experiments

ggugggggUUGGAGGCGUGGGUUUUagaaccuaucccuuucuagcccugagca
(.(.(((((((((((.(((((((....))))))).))..))))))))).).).

Structure

- g g         --  C       U 
 g u ggggUUGGA  GG GUGGGUU U
 | | |||||||||  || |||||||  
 c a ucccgaucu  cc uauccaa a
a g g         uu  c       g 

Annotation confidence Not enough data

Genome context

chr3: 48196564-48196616 [+]

Disease association

hsa-mir-4443 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4443

• Accession: MIMAT0018961
• Description: Homo sapiens hsa-miR-4443 mature miRNA
• Sequence: 9 - UUGGAGGCGUGGGUUUU - 25
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127