Stem-loop hsa-mir-4423

Accession

MI0016760

Symbol

HGNC: MIR4423

Description

Homo sapiens hsa-mir-4423 precursor miRNA mir-4423

Gene
family

RF03487; mir-4423

Literature search

5 open access papers mention hsa-mir-4423
(19 sentences)

Sequence

742 reads, 19 reads per million, 57 experiments

aucauguacugcAGUUGCCUUUUUGUUCCCAUGCuguuuaagccuagcAUAGGCACCAAAAAGCAACAAcaguaugugaa
.((((((((((..(((((.((((((...((((((((........)))))).))...)))))))))))..)))))))))).

Structure

a          cA     C      UUC  -      uuu 
 ucauguacug  GUUGC UUUUUG   CC AUGCug   a
 ||||||||||  ||||| ||||||   || ||||||    
 aguguaugac  CAACG AAAAAC   GG UAcgau   a
a          AA     -      CAC  A      ccg 

Annotation confidence High

Genome context

chr1: 85133794-85133873 [+]

Disease association

hsa-mir-4423 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4423-5p

• Accession: MIMAT0019232
• Description: Homo sapiens hsa-miR-4423-5p mature miRNA
• Sequence: 13 - AGUUGCCUUUUUGUUCCCAUGC - 34
• Evidence: experimental ; Illumina [2,4]

Mature hsa-miR-4423-3p

• Accession: MIMAT0018936
• Description: Homo sapiens hsa-miR-4423-3p mature miRNA
• Sequence: 49 - AUAGGCACCAAAAAGCAACAA - 69
• Evidence: experimental ; Illumina [1-2,4]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127


2. PubMed ID: 21199797
   Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene
   "Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C"
   "Cancer Res (2011) 71:78-86


3. PubMed ID: 21911355
   miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
   "Friedlander MR, Mackowiak SD, Li N, Chen W, Rajewsky N"
   "Nucleic Acids Res (2012) 40:37-52


4. PubMed ID: 21807764
   Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome
   "Joyce CE, Zhou X, Xia J, Ryan C, Thrash B, Menter A, Zhang W, Bowcock AM"
   "Hum Mol Genet (2011) 20:4025-4040


5. PubMed ID: 24158479
   MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis
   "Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A"
   "Proc Natl Acad Sci U S A (2013) 110:18946-18951