Accession
MI0014187
Symbol
HGNC:
MIR3158-2
Description
Homo sapiens
hsa-mir-3158-2 precursor miRNA mir-3158
Gene
family?
family?
RF03941;
mir-3158
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR3158-2 is a microRNA implicated in the genetic region associated with Split-Hand/Foot Malformation (SHFM), a congenital limb disorder [PMC5003447]. This microRNA is entirely encompassed within a deletion region that also includes parts of the DPCD and FBXW4 genes, as well as the entirety of MIR3158-1 [PMC5003447]. In SHFM cases, duplications often contain MIR3158-2 along with other genes such as LBX1, BTRC, POLL, and DPCD; these duplications are consistent across cases with microarray data and those without [PMC5003447]. Notably, in SHFM cases with two discontinuous duplications at chromosome 10q24.31–q24.32, MIR3158-2 is located in the telomeric duplicated segment along with POLL and parts of DPCD and FBXW4 [PMC5003447'>PMC5003447]. Even in Patient 18 who exhibits atypical SHFM features such as short palm, small feet, hypertelorism, intellectual disability, and obesity—a 241.59 kb duplication still includes MIR3158-2 [PMC5003447]. This suggests that MIR3158-2 may play a role in the phenotypic manifestations of SHFM whether or not classical symptoms are present [PMC5003447].
Sequence
6644
reads,
97
reads per million, 73 experiments
auucaggccgguCCUGCAGAGAGGAAGCCCUUCcaauaccuguaagcagAAGGGCUUCCUCUCUGCAGGACcggccugaau
(((((((((((((((((((((((((((((((((...............)))))))))))))))))))))))))))))))))
(((((((((((((((((((((((((((((((((...............)))))))))))))))))))))))))))))))))
Structure
caauac
auucaggccgguCCUGCAGAGAGGAAGCCCUUC c
||||||||||||||||||||||||||||||||| u
uaaguccggcCAGGACGUCUCUCCUUCGGGAAg g
acgaau
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr10: 101601417-101601497 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-3158-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-3158-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-3158-3p
| Accession | MIMAT0015032 |
| Description | Homo sapiens hsa-miR-3158-3p mature miRNA |
| Sequence | 50 - AAGGGCUUCCUCUCUGCAGGAC - 71 |
| Evidence |
experimental
Illumina [1-2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-3158-5p
| Accession | MIMAT0019211 |
| Description | Homo sapiens hsa-miR-3158-5p mature miRNA |
| Sequence | 13 - CCUGCAGAGAGGAAGCCCUUC - 33 |
| Evidence | not_experimental |
References
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