Stem-loop hsa-mir-378b

Accession

MI0014154

Symbol

HGNC: MIR378B

Description

Homo sapiens hsa-mir-378b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR378B is a microRNA implicated in various cellular processes, including the regulation of gene expression in cell proliferation and the maintenance of neural stem/progenitor cells [PMC9774417; PMC7041117].'>PMC7041117].. It is functionally annotated and associated with the response to ANIT, a compound that affects liver cells, indicating its role in cellular response to external stimuli [PMC6349826]. MIR378B expression is influenced by circ_0078710, which acts as a sponge for miR-378b; when circ_0078710 is downregulated by CUR, MIR378B levels increase, leading to the downregulation of PRIM2 [PMC9774417]. While MIR378B is involved in neural stem/progenitor cell regulation, the direct targeting of Usp22 by MIR378B is not explicitly stated; instead, Usp22 is involved in neural stem/progenitor cell regulation through Hes1 in the developing mouse brain [PMC7041117]. Additionally, MIR378B has been identified as upregulated in certain tumor types and shows differential expression patterns between brain tissues such as the striatum and cortex [PMC8242244; PMC5764268].. Furthermore, MIR378B levels were found to be significantly elevated when miR-378b was inhibited in CpG-stimulated dendritic cells (DCs), suggesting its role in immune responses [PMC6963666].

Literature search

193 open access papers mention hsa-mir-378b
(923 sentences)

Sequence

3698 reads, 30 reads per million, 50 experiments

ggucauugagucuucaaggcuaguggaaagagcACUGGACUUGGAGGCAGAAagacc
((((.((..(((((((((.((((((.......)))))).)))))))))..)).))))

Structure

    a  ga         g      ga 
gguc uu  gucuucaag cuagug  a
|||| ||  ||||||||| ||||||  a
ccag AA  CGGAGGUUC GGUCAc  g
    a  GA         A      ga 

Annotation confidence Not enough data

Genome context

chr3: 10330229-10330285 [+]

Disease association

hsa-mir-378b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-378b

• Accession: MIMAT0014999
• Description: Homo sapiens hsa-miR-378b mature miRNA
• Sequence: 34 - ACUGGACUUGGAGGCAGAA - 52
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20300190
   Characterization of the Melanoma miRNAome by Deep Sequencing
   "Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK"
   "PLoS One (2010) 5:e9685