Accession
MI0006443
Symbol
HGNC:
MIR1306
Description
Homo sapiens
hsa-mir-1306 precursor miRNA mir-1306
Gene
family?
family?
RF01014;
mir-1306
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1306 is a microRNA (miRNA) that is expressed in the brain and conserved in mice, suggesting a functional significance across species [PMC4487986]. It is one of the miRNAs that are upregulated in response to IFN-γ stimulation, indicating its potential involvement in immune responses [PMC8010072]. MIR1306 is also highly expressed in reproductive organs and may play a role in post-transcriptional processing that affects mRNA stability, which could be important for pregnancy outcomes [PMC8645989]. This miRNA has been shown to inhibit the production of proinflammatory cytokines by targeting key genes, which could be relevant for inflammatory processes [PMC8155903]. Additionally, MIR1306 affects cytokine expression through its interaction with the TLR4 pathway [PMC8155903]. The gene for MIR1306 overlaps with the DGCR8 coding region and is conserved among primates, suggesting a potential regulatory role within gene networks [PMC7357559]. Furthermore, MIR1306 has been identified as one of the most frequently affected miRNAs in congenital anomalies of the kidney and urinary tract (CAKUT), supporting its potential involvement in this condition as well [PMC9587983].
Literature search
13 open access papers mention hsa-mir-1306
(54 sentences)
(54 sentences)
Sequence
4710
reads,
100
reads per million, 97 experiments
gugagcagucuccaCCACCUCCCCUGCAAACGUCCAguggugcagagguaauggACGUUGGCUCUGGUGGUGauggacaguccga
.((.((.((((.(((((((......((.((((((((.((.(.....).)).)))))))).))...)))))))..)))).)).)).
.((.((.((((.(((((((......((.((((((((.((.(.....).)).)))))))).))...)))))))..)))).)).)).
Structure
g a a -c UCCCCU A g g g ug gc gucu caCCACC GC AACGUCCA ug u c || || |||| ||||||| || |||||||| || | a gc ug cagg GUGGUGG CG UUGCAggu au g g a c a ua ---UCU G a g a
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr22: 20086058-20086142 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-1306
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-1306 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1306-3p
| Accession | MIMAT0005950 |
| Description | Homo sapiens hsa-miR-1306-3p mature miRNA |
| Sequence | 55 - ACGUUGGCUCUGGUGGUG - 72 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-1306-5p
| Accession | MIMAT0022726 |
| Description | Homo sapiens hsa-miR-1306-5p mature miRNA |
| Sequence | 15 - CCACCUCCCCUGCAAACGUCCA - 36 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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