Stem-loop hsa-mir-1291

Accession

MI0006353

Symbol

HGNC: MIR1291

Description

Homo sapiens hsa-mir-1291 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1291 is a microRNA that has been implicated in various cellular processes and diseases. It has been identified as a regulator of the Rho GTPase activating protein 29 (ArhGAP29) through gene ontology and various database analyses [PMC5647010]. In the context of resistance to tamoxifen in breast cancer cells, MIR1291 is slightly upregulated, suggesting a potential role in the development of resistance [PMC3402532]. Moreover, MIR1291 has been associated with the regulation of glucose transporters GLUT1 and GLUT3 in different cancer cell types, indicating its involvement in metabolic regulation [PMC9663470]. In studies examining exhaled breath condensates, MIR1291 expression was found to be downregulated specifically in asthmatic patients compared to healthy individuals [PMC8196952]. Additionally, after stimulation with IFN-γ, MIR1291 was among the top 10 upregulated microRNAs, highlighting its potential role in immune response modulation [PMC8010072].

Literature search

11 open access papers mention hsa-mir-1291
(126 sentences)

Sequence

1381 reads, 203 reads per million, 74 experiments

gguagaauuccagUGGCCCUGACUGAAGACCAGCAGUuguacuguggcuguugguuucaagcagaggccuaaaggacugucuuccug
((.(((..(((...(((((((.((..((((((((((((.......))))))))))))..))))).))))....)))...))).))..

Structure

--  u   -au   -agU    -   A  GA            gu 
  gg aga   ucc    GGCC CUG CU  AGACCAGCAGUu  a
  || |||   |||    |||| ||| ||  ||||||||||||  c
  cc ucu   agg    ccgg gac ga  uuugguugucgg  u
gu  u   guc   aaau    a   -  ac            ug 

Annotation confidence Not enough data

Genome context

chr12: 48654444-48654530 [-]

Disease association

hsa-mir-1291 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1291

• Accession: MIMAT0005881
• Description: Homo sapiens hsa-miR-1291 mature miRNA
• Sequence: 14 - UGGCCCUGACUGAAGACCAGCAGU - 37
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621