Stem-loop hsa-mir-760

Accession

MI0005567

Symbol

HGNC: MIR760

Description

Homo sapiens hsa-mir-760 precursor miRNA mir-760

Gene
family

RF00915; mir-760

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR760 is a microRNA that has been observed to have varying expression levels in different types of cancer, such as ovarian, liver, and colorectal cancers [PMC7462065]. The alteration in the expression of MIR760, whether it is overexpressed or underexpressed, has been implicated in the development of these cancers [PMC7462065]. Studies have shown that when MIR760 is suppressed or when its binding site is mutated, there is a notable increase in the levels of the ATXN1 protein [PMC7462065]. Since ATXN1 protein dysregulation is linked to neurodegenerative diseases, MIR760 may have a regulatory role in the expression of genes that are crucial in both oncogenesis and neurodegeneration [PMC7462065].

Literature search

20 open access papers mention hsa-mir-760
(159 sentences)

Sequence

6551 reads, 305 reads per million, 63 experiments

ggcgcgucgccccccucaguccaccagagcccggauaccucagaaauuCGGCUCUGGGUCUGUGGGGAgcgaaaugcaac
.(((..((((.((((.(((....((((((((.((((.........))))))))))))..))).)))).))))..)))...

Structure

--g   cg    c    u   ucca        c    acc 
   gcg  ucgc cccc cag    ccagagcc ggau   u
   |||  |||| |||| |||    |||||||| ||||   c
   cgu  agcg GGGG GUC    GGUCUCGG Cuua   a
caa   aa    A    U   --UG        -    aag 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr1: 93846832-93846911 [+]

Disease association

hsa-mir-760 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-760

• Accession: MIMAT0004957
• Description: Homo sapiens hsa-miR-760 mature miRNA
• Sequence: 49 - CGGCUCUGGGUCUGUGGGGA - 68
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298