miRBase entry: hsa-mir-760

Stem-loop hsa-mir-760

Homo sapiens hsa-mir-760 precursor miRNA
Gene family
MIPF0000395; mir-760

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR760 is a microRNA that has been implicated in various types of cancer, such as ovarian, liver, and colorectal cancer (Liao et al. [PMC7462065]). In a study conducted by Liao et al., it was observed that alterations in MIR760 expression, both up and down, were associated with these forms of cancer (Liao et al. [PMC7462065]). Additionally, the study found that inhibiting MIR760 or mutating its binding site in the 5′ UTR of ATXN1 led to a significant increase in ATXN1 protein levels (Liao et al. [PMC7462065]). This suggests that MIR760 may play a role in regulating ATXN1 expression. The findings highlight the potential importance of MIR760 as a therapeutic target or biomarker for cancer treatment and diagnosis. Further research is needed to fully understand the mechanisms by which MIR760 influences cancer development and progression.

Literature search
20 open access papers mention hsa-mir-760
(159 sentences)


6551 reads, 305 reads per million, 63 experiments

--g   cg    c    u   ucca        c    acc 
   gcg  ucgc cccc cag    ccagagcc ggau   u
   |||  |||| |||| |||    |||||||| ||||   c
   cgu  agcg GGGG GUC    GGUCUCGG Cuua   a
caa   aa    A    U   --UG        -    aag 

Annotation confidence High
Do you think this miRNA is real?
This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context
chr1: 93846832-93846911 [+]

Disease association
hsa-mir-760 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-760

Accession MIMAT0004957
Description Homo sapiens hsa-miR-760 mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16954537
    Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
    "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
    "Genome Res (2006) 16:1289-1298