Stem-loop hsa-mir-885

Accession

MI0005560

Symbol

HGNC: MIR885

Description

Homo sapiens hsa-mir-885 precursor miRNA mir-885

Gene
family

RF01015; mir-885

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR885 is a microRNA implicated in various cellular processes and has been observed in peak-calling annotation alongside other genes at the 5'UTR region [PMC6356444]. Its expression was found to be decreased in sFRP4 SI cells but was upregulated four-fold in sFRP4 OE cells compared to control U87 cells [PMC6356444]. MIR885 is linked to the p53 pathway and has been localized in the cytoplasm, as demonstrated by in situ hybridization [PMC6356444]. It plays a role in autophagy, acting as a negative regulator by targeting various autophagy-related genes [PMC4990999]. MIR885 has also been associated with cellular migration, where its upregulation stimulates migration and downregulates IGFBP-5 [PMC9203274]. It is expressed under the control of the CMV promoter and can suppress ISRE activities induced by IFN-α stimulation [PMC3434395]. Furthermore, MIR885 interacts with p73ΔEx2/3 to enhance stemness and self-renewal capacity in melanoma cells [PMC7765507], while its expression can be influenced by differential methylation of CG dinucleotides within its promoter region [PMC9847511]. Lastly, MIR885 has been identified as a potential tumor suppressor with brain/cerebellum-restricted expression that targets IGFR [PMC8506118].

Literature search

38 open access papers mention hsa-mir-885
(236 sentences)

Sequence

1421 reads, 59 reads per million, 69 experiments

ccgcacucucUCCAUUACACUACCCUGCCUCUucuccaugagAGGCAGCGGGGUGUAGUGGAUAgagcacgggu
(((..((((.(((((((((((.(((((((((((......))))))))).))))))))))))).))))..)))..

Structure

--   ca    c           A  -         cu 
  ccg  cucu UCCAUUACACU CC CUGCCUCUu  c
  |||  |||| ||||||||||| || |||||||||   
  ggc  gagA AGGUGAUGUGG GG GACGGAgag  c
ug   ac    U           -  C         ua 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr3: 10394489-10394562 [-]

Disease association

hsa-mir-885 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-885-5p

• Accession: MIMAT0004947
• Description: Homo sapiens hsa-miR-885-5p mature miRNA
• Sequence: 11 - UCCAUUACACUACCCUGCCUCU - 32
• Evidence: experimental ; cloned [2]

Mature hsa-miR-885-3p

• Accession: MIMAT0004948
• Description: Homo sapiens hsa-miR-885-3p mature miRNA
• Sequence: 43 - AGGCAGCGGGGUGUAGUGGAUA - 64
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298