Stem-loop hsa-mir-190b

Accession

MI0005545

Symbol

HGNC: MIR190B

Description

Homo sapiens hsa-mir-190b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

hsa-mir-190b, a microRNA, has been observed to play a regulatory role in the expression of FGF2, a fibroblast growth factor [PMC8923688]. It has been found to be upregulated, which in turn contributes to the downregulation of FGF2 [PMC8923688]. This regulatory action of hsa-mir-190b is significant as it helps in mitigating the inflammatory response and vascular endothelial injury [PMC8923688]. Additionally, hsa-mir-190b is involved in the activation of FGF2 and FGFR1 protein expression, which are critical components in vascular biology [PMC8923688]. However, it is important to note that hsa-mir-190b has also been identified as one of the most significantly downregulated microRNAs alongside hsa-miR-449a [PMC7499949]. This contrasting observation suggests that hsa-mir-190b may have complex regulatory roles that could vary depending on the cellular context or experimental conditions [PMC7499949; PMC8923688]..

Literature search

49 open access papers mention hsa-mir-190b
(225 sentences)

Sequence

3141 reads, 65 reads per million, 66 experiments

ugcuucugugUGAUAUGUUUGAUAUUGGGUUGuuuaauuaggaaccaACUAAAUGUCAAACAUAUUCUuacagcagcag
((((.(((((.(((((((((((((((.((((((((......))).))))).)))))))))))))))..))))).)))).

Structure

-    u     -U               G     -   aa 
 ugcu cugug  GAUAUGUUUGAUAUU GGUUG uuu  u
 |||| |||||  ||||||||||||||| ||||| |||   
 acga gacau  UUAUACAAACUGUAA UCAac aag  u
g    c     UC               A     c   ga 

Annotation confidence Not enough data

Genome context

chr1: 154193665-154193743 [-]

Disease association

hsa-mir-190b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-190b-5p

• Accession: MIMAT0004929
• Description: Homo sapiens hsa-miR-190b-5p mature miRNA
• Sequence: 11 - UGAUAUGUUUGAUAUUGGGUUG - 32
• Evidence: not_experimental

Mature hsa-miR-190b-3p

• Accession: MIMAT0037332
• Description: Homo sapiens hsa-miR-190b-3p mature miRNA
• Sequence: 48 - ACUAAAUGUCAAACAUAUUCU - 68
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414