Stem-loop hsa-mir-876

Accession

MI0005542

Symbol

HGNC: MIR876

Description

Homo sapiens hsa-mir-876 precursor miRNA mir-876

Gene
family

RF00935; mir-876

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR876 is a gene encoding for microRNAs, specifically miR-876–3p and miR-876–5p, which are implicated in the regulation of bone geometry and appendicular lean mass (ALM) [PMC3210160]. In a bivariate genome-wide association study (GWAS) conducted among Chinese individuals, MIR876, along with MIR873, was associated with femoral neck bone geometry and ALM [PMC3210160]. This study identified a cluster of 11 single nucleotide polymorphisms (SNPs) within the genomic regions of MIR876 and MIR873 that showed a strong association with ALM-BR in the Chinese population [PMC3210160]. Notably, two of these SNPs are located in the promoter region of MIR876 [PMC3210160]'>PMC3210160], which could suggest potential regulatory effects on gene expression. However, these associations were not replicated in US Caucasians [PMC3706967], indicating possible ethnic differences in genetic susceptibility. The exact biological mechanisms by which MIR876 influences bone and muscle metabolism remain to be elucidated [PMC3210160]. Additionally, research has identified miR-876-3p as a methylation-sensitive microRNA that could be involved in gene regulation through epigenetic modifications [PMC9582525]. In certain glioblastomas (pGBMs), deletions at 9p21.3 that include the MIR876 gene have been observed as well [PMC6388501], suggesting its potential role in disease pathology.

Literature search

11 open access papers mention hsa-mir-876
(15 sentences)

Sequence

724 reads, 13 reads per million, 59 experiments

ugaagugcugUGGAUUUCUUUGUGAAUCACCAuaucuaagcuaauguggUGGUGGUUUACAAAGUAAUUCAuagugcuuca
((((((((((((((((.((((((((((((((((..(.........)..)))))))))))))))).))))))))))))))))

Structure

                U                au uaa 
ugaagugcugUGGAUU CUUUGUGAAUCACCAu  c   g
|||||||||||||||| ||||||||||||||||  |   c
acuucgugauACUUAA GAAACAUUUGGUGGUg  g   u
                U                gu uaa 

Annotation confidence High

Genome context

chr9: 28863626-28863706 [-]

Disease association

hsa-mir-876 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-876-5p

• Accession: MIMAT0004924
• Description: Homo sapiens hsa-miR-876-5p mature miRNA
• Sequence: 11 - UGGAUUUCUUUGUGAAUCACCA - 32
• Evidence: experimental ; cloned [1]

Mature hsa-miR-876-3p

• Accession: MIMAT0004925
• Description: Homo sapiens hsa-miR-876-3p mature miRNA
• Sequence: 50 - UGGUGGUUUACAAAGUAAUUCA - 71
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414