miRBase entry: hsa-mir-449c

Stem-loop hsa-mir-449c

Homo sapiens hsa-mir-449c precursor miRNA
Gene family
MIPF0000133; mir-449

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR449C is a microRNA that has been found to be upregulated upon air exposure in an AhR-dependent manner [PMC4999520]. It is part of a hyper-conserved region that includes the miR34a/b/c, MIR449C, and let-7a miRNA seed sequence regions [PMC6576772]. MIR449C is highly homologous to miR449a and miR449b [PMC6412851]. Increased expression of MIR449C has been associated with the generation of mo-MDSCs, and it plays a role in regulating brain development, motile ciliogenesis, and spermatogenesis [PMC7528684]. In liver cancer, MIR449C acts as a tumor suppressor by promoting cell death and inhibiting cell migration [PMC7528684]. Overexpression of MIR449C leads to the expansion of mo-MDSCs, while knockdown inhibits differentiation of myeloid progenitor cells to mo-MDSCs [PMC7528684]. STAT6 has been identified as a downstream target and functional mediator of MIR449C during myeloid progenitor cell differentiation [PMC7528684]. Additionally, MIR449C has been identified as an important regulator of proliferation and invasion in nonsmall cell lung cancer and gastric cancer [PMC7528684]. It is part of the isomiR families that show altered expression in various conditions such as miR125a/b, miR10a/b, miR92a/b, and miR99a [PMC8705090]. In Emca3 gene region there are several genes that encode small RNAs including miR449a, MIR449C, and miR582 [PMC4132170].

Literature search
69 open access papers mention hsa-mir-449c
(386 sentences)


930 reads, 35 reads per million, 42 experiments

   --g      gu    U   C      UU               u 
gcu   ggaugu  cagg AGG AGUGUA  GCUAGCGGCUGUuaa g
|||   ||||||  |||| ||| ||||||  ||||||||||||||| a
cga   cuuacg  GUCU UCC UCACGU  UGAUCGUUgacaauu u
   aga      uU    C   -      --               u 

Annotation confidence High
Do you think this miRNA is real?
This sequence was identified as a miRNA candidate by Berezikov et al. using the RAKE techniques [1]. Expression was later confirmed by Wyman et al. [2].

Genome context
chr5: 55172262-55172353 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-449c
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-449c is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-449c is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-449c is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-449c-5p

Accession MIMAT0010251
Description Homo sapiens hsa-miR-449c-5p mature miRNA
Evidence experimental
RAKE [1], 454 [2]
Database links
Predicted targets

Mature hsa-miR-449c-3p

Accession MIMAT0013771
Description Homo sapiens hsa-miR-449c-3p mature miRNA
Evidence experimental
454 [2]


  1. PubMed ID: 16954537
    Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
    "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
    "Genome Res (2006) 16:1289-1298

  2. PubMed ID: 19390579
    Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries
    Wyman SK, Parkin RK, Mitchell PS, Fritz BR, O'Briant K, Godwin AK, Urban N, Drescher CW, Knudsen BS, Tewari M
    PLoS One (2009) 4:e5311