Stem-loop hsa-mir-454

Accession

MI0003820

Symbol

HGNC: MIR454

Description

Homo sapiens hsa-mir-454 precursor miRNA mir-454

Gene
family

RF00746; mir-454

Literature search

39 open access papers mention hsa-mir-454
(284 sentences)

Sequence

55772 reads, 224 reads per million, 117 experiments

ucuguuuaucaccagauccuagaACCCUAUCAAUAUUGUCUCUGCuguguaaauaguucugagUAGUGCAAUAUUGCUUAUAGGGUuuugguguuuggaaagaacaaugggcagg
.(((((((((.((((((.((((((((((((((((((((((((.(((((....)))))...)))....)))))))))...)))))))))))).))))))...))....))))))).

Structure

u       ----  --a      c            ---         ----   --U     g 
 cuguuua    uc   ccagau cuagaACCCUAU   CAAUAUUGU    CUC   GCugu u
 |||||||    ||   |||||| ||||||||||||   |||||||||    |||   |||||  
 gacgggu    ag   gguuug gguuuUGGGAUA   GUUAUAACG    gag   ugaua a
g       aaca  aaa      u            UUC         UGAU   ucu     a 

Annotation confidence High

Comments

The mature miRNA sequences were named miR-454-5p and miR-454-3p in [1] and here. Landgraf et al. showed that the 3' product is the predominant one [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr17: 59137758-59137872 [-]

Disease association

hsa-mir-454 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-454-5p

• Accession: MIMAT0003884
• Description: Homo sapiens hsa-miR-454-5p mature miRNA
• Sequence: 24 - ACCCUAUCAAUAUUGUCUCUGC - 45
• Evidence: experimental ; cloned [1-2]

Mature hsa-miR-454-3p

• Accession: MIMAT0003885
• Description: Homo sapiens hsa-miR-454-3p mature miRNA
• Sequence: 64 - UAGUGCAAUAUUGCUUAUAGGGU - 86
• Evidence: experimental ; cloned [1-2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298