Accession
MI0003757
Symbol
HGNC:
MIR758
Description
Homo sapiens
hsa-mir-758 precursor miRNA mir-379
Gene
family?
family?
RF04292;
mir-379
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR758 is a microRNA (miRNA) that has been studied in the context of its expression in relation to certain treatments and its location within the genome. Treatment with a specific agent for 24 hours was found to reduce the expression of several miRNAs, including MIR758, as shown by qRT-PCR results [PMC6100038]. MIR758, along with other miRNAs, has been identified as having a role in inhibiting the expression or function of the ATP-binding cassette transporter A1 (ABCA1) [PMC6100038]. However, there is no evidence provided that MIR758 expression is associated with cellular processes such as proliferation and differentiation, nor that it has been implicated in neuroblastoma progression [PMC9866967]. In canine genomes, MIR758 is notably located within a cluster of differentially expressed (DE) miRNAs on chromosome 8 [PMC8376273]. This cluster includes several other miRNAs that have been profiled for their expression levels [PMC10148110].
Literature search
14 open access papers mention hsa-mir-758
(44 sentences)
(44 sentences)
Sequence
729
reads,
57
reads per million, 48 experiments
gccuggauacaugaGAUGGUUGACCAGAGAGCACACgcuuuauuugugccgUUUGUGACCUGGUCCACUAACCcucaguaucuaaugc
...(((((((.((((.((((.((((((.(.(((.((((.........).))).)))..))))))).))))...)))))))))))....
...(((((((.((((.((((.((((((.(.(((.((((.........).))).)))..))))))).))))...)))))))))))....
Structure
-gcc a --A U A -A C - uuu
uggauac ugaG UGGU GACCAG G GCA ACg c a
||||||| |||| |||| |||||| | ||| ||| | u
aucuaug acuc AUCA CUGGUC C UGU Ugc g u
cgua - CCA C - AG U c ugu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101026020-101026107 [+]
Clustered miRNAs
12 other miRNAs are < 10 kb from hsa-mir-758
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-758 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-758-3p
| Accession | MIMAT0003879 |
| Description | Homo sapiens hsa-miR-758-3p mature miRNA |
| Sequence | 52 - UUUGUGACCUGGUCCACUAACC - 73 |
| Evidence |
experimental
cloned [1-2], SOLiD [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-758-5p
| Accession | MIMAT0022929 |
| Description | Homo sapiens hsa-miR-758-5p mature miRNA |
| Sequence | 15 - GAUGGUUGACCAGAGAGCACAC - 36 |
| Evidence |
experimental
SOLiD [3] |
| Database links |
|
| Predicted targets |
|
References
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