Accession
MI0003686
Symbol
HGNC:
MIR542
Description
Homo sapiens
hsa-mir-542 precursor miRNA mir-542
Gene
family?
family?
RF00755;
mir-542
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR542 is a microRNA implicated in the regulation of tumor suppressive functions in glioblastoma multiforme (GBM) [PMC7575175]. It has been identified as a potential tumor suppressor, with its expression affecting the migration and proliferation of U251 glioma cells [PMC7575175]. MIR542 targets the AEG-1 gene, which is involved in the epithelial-mesenchymal transition (EMT) process, and downregulation of AEG-1 by MIR542 leads to a suppression of EMT, thereby inhibiting U251 cell aggressiveness and proliferation [PMC7575175]. The functional role of MIR542 in GBM and its underlying mechanisms are not fully understood; however, it has been shown to play a regulatory role in cancer development [PMC7575175]. The identification of targeted genes such as AEG-1 by MIR542 provides new insights into its role in tumor suppression and offers potential therapeutic targets for glioma treatment [PMC7575175].
Literature search
52 open access papers mention hsa-mir-542
(251 sentences)
(251 sentences)
Sequence
41785
reads,
402
reads per million, 112 experiments
cagaucucagacaucUCGGGGAUCAUCAUGUCACGAGAuaccagugugcacuUGUGACAGAUUGAUAACUGAAAggucugggagccacucaucuuca
....((((((((...((((..((((...(((((((((.(((....)))..)))))))))...))))..))))...))))))))..............
....((((((((...((((..((((...(((((((((.(((....)))..)))))))))...))))..))))...))))))))..............
Structure
----------caga auc GG UCA -A c
ucucagac UCGG AUCA UGUCACGAG uac a
|||||||| |||| |||| ||||||||| |||
agggucug AGUC UAGU ACAGUGUuc gug g
acuucuacucaccg gAA AA UAG ac u
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chrX: 134541341-134541437 [-]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-542
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-542 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-542-5p
| Accession | MIMAT0003340 |
| Description | Homo sapiens hsa-miR-542-5p mature miRNA |
| Sequence | 16 - UCGGGGAUCAUCAUGUCACGAGA - 38 |
| Evidence |
experimental
cloned [1-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-542-3p
| Accession | MIMAT0003389 |
| Description | Homo sapiens hsa-miR-542-3p mature miRNA |
| Sequence | 53 - UGUGACAGAUUGAUAACUGAAA - 74 |
| Evidence |
experimental
cloned [1-2] |
| Database links |
|
| Predicted targets |
|
References
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