Accession
MI0003685
Symbol
HGNC:
MIR421
Description
Homo sapiens
hsa-mir-421 precursor miRNA mir-95
Gene
family?
family?
RF04053;
mir-95
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MicroRNA 421 (MIR421) is a non-coding RNA molecule that plays a significant role in various biological processes, including cancer progression and the body's response to oxidative stress [PMC7802300; PMC9313271].. In gastric cancer, MIR421 levels in gastric juice are notably different from those in benign gastric diseases [PMC6924079]. MIR421, along with MIR27a-3p and hemoglobin levels in feces, has been utilized to develop a model that accurately identifies patients with colorectal cancer (CRC), demonstrating superior diagnostic performance compared to fecal hemoglobin concentration alone [PMC9318064]. Additionally, MIR421 has been implicated in the negative regulation of the ACE2 receptor by targeting its 3′-UTR [PMC7653219], and its overexpression is associated with increased proliferation of cancer cells in breast and non-small cell lung cancers [PMC7802300]. Furthermore, MIR421 is part of a three-miRNA signature that predicts gastrointestinal (GI) involvement and clinical outcomes [PMC7802300]'>PMC7802300], and it has been shown to interfere with DNA repair by suppressing ataxia-telangiectasia mutated expression, thereby enhancing GI [PMC7802300]. Despite its oncogenic role in various cancers, MIR421 may also act as a tumor suppressor in certain contexts such as prostate cancer cells [PMC6089101], illustrating its complex role in oncogenesis.
Literature search
50 open access papers mention hsa-mir-421
(142 sentences)
(142 sentences)
Sequence
47199
reads,
455
reads per million, 104 experiments
gcacauuguaggccucauuaaauguuuguugaaugaaaaaaugaaucAUCAACAGACAUUAAUUGGGCGCcugcucugugaucuc
.((((..((((((((((...((((((((((((.(((.........)))))))))))))))...)))).))))))..)))).....
.((((..((((((((((...((((((((((((.(((.........)))))))))))))))...)))).))))))..)))).....
Structure
----g uu - uua a aaa
caca guaggc cuca aauguuuguuga uga a
|||| |||||| |||| |||||||||||| ||| a
gugu cgucCG GGGU UUACAGACAACU Acu u
cucua cu C UAA - aag
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 74218377-74218461 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-421
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-421 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-421
| Accession | MIMAT0003339 |
| Description | Homo sapiens hsa-miR-421 mature miRNA |
| Sequence | 48 - AUCAACAGACAUUAAUUGGGCGC - 70 |
| Evidence |
experimental
Microarray [1], SAGE [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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