Stem-loop hsa-mir-421

Accession

MI0003685

Symbol

HGNC: MIR421

Description

Homo sapiens hsa-mir-421 precursor miRNA mir-95

Gene
family

RF04053; mir-95

Literature search

50 open access papers mention hsa-mir-421
(142 sentences)

Sequence

47198 reads, 206 reads per million, 104 experiments

gcacauuguaggccucauuaaauguuuguugaaugaaaaaaugaaucAUCAACAGACAUUAAUUGGGCGCcugcucugugaucuc
.((((..((((((((((...((((((((((((.(((.........)))))))))))))))...)))).))))))..)))).....

Structure

----g    uu      -    uua            a   aaa 
     caca  guaggc cuca   aauguuuguuga uga   a
     ||||  |||||| ||||   |||||||||||| |||   a
     gugu  cgucCG GGGU   UUACAGACAACU Acu   u
cucua    cu      C    UAA            -   aag 

Annotation confidence High

Genome context

chrX: 74218377-74218461 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-421

Disease association

hsa-mir-421 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-421

• Accession: MIMAT0003339
• Description: Homo sapiens hsa-miR-421 mature miRNA
• Sequence: 48 - AUCAACAGACAUUAAUUGGGCGC - 70
• Evidence: experimental ; Microarray [1], SAGE [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692