Accession
MI0003667
Symbol
HGNC:
MIR652
Description
Homo sapiens
hsa-mir-652 precursor miRNA mir-652
Gene
family?
family?
RF00872;
mir-652
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR652 is a microRNA that has been observed to have varying expression levels in different biological contexts and diseases. In the subgroup of early-onset myasthenia gravis (EOMG), MIR652 was found to be expressed at low levels [PMC3956820]. In contrast, in both knockout (KO) and knock-in (KI) mouse models, MIR652 was upregulated, which has been associated with the negative regulation of spermatid differentiation [PMC10001410]. In the case of breast cancer, MIR652 expression was generally lower in serum samples from cancer cases compared to controls [PMC9967215]. Furthermore, MIR652 has been identified as a potential biomarker for breast cancer in at least two independent clinical studies that analyzed serum, plasma, or whole blood samples [PMC9967215]. Kaplan-Meier analysis included MIR652 as part of a four-miRNA signature that could help predict tumor relapse and overall survival (OS) in patients with triple-negative breast cancer (TNBC), suggesting its potential prognostic value [PMC7392022].
Literature search
34 open access papers mention hsa-mir-652
(107 sentences)
(107 sentences)
Sequence
50720
reads,
420
reads per million, 123 experiments
acgaauggcuaugcacugcaCAACCCUAGGAGAGGGUGCCAUUCAcauagacuauaauugAAUGGCGCCACUAGGGUUGUGcagugcacaaccuacac
......((...((((((((((((((((((.....(((((((((((..((.....))..))))))))))).))))))))))))))))))...)).....
......((...((((((((((((((((((.....(((((((((((..((.....))..))))))))))).))))))))))))))))))...)).....
Structure
acgaau cua GAGAG ca g
gg ugcacugcaCAACCCUAG GGUGCCAUUCA ua a
|| |||||||||||||||||| ||||||||||| || c
cc acgugacGUGUUGGGAUC CCGCGGUAAgu au u
-cacau aac ----A ua a
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 3' end of the miRNA is offset with respect to previous annotations. miR-652 cloned in [2] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
Genome context
chrX: 110055329-110055426 [+]
Disease association
hsa-mir-652 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-652-3p
| Accession | MIMAT0003322 |
| Description | Homo sapiens hsa-miR-652-3p mature miRNA |
| Sequence | 61 - AAUGGCGCCACUAGGGUUGUG - 81 |
| Evidence |
experimental
Microarray [1], SAGE [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-652-5p
| Accession | MIMAT0022709 |
| Description | Homo sapiens hsa-miR-652-5p mature miRNA |
| Sequence | 21 - CAACCCUAGGAGAGGGUGCCAUUCA - 45 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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