Stem-loop hsa-mir-615

Accession

MI0003628

Symbol

HGNC: MIR615

Description

Homo sapiens hsa-mir-615 precursor miRNA mir-615

Gene
family

RF00879; mir-615

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR615 is a microRNA encoded within the HOXC cluster on chromosome 13 and is implicated in various cancers, including prostate, colon, and osteosarcoma (OS) [PMC4620477][PMC3037319][PMC9441498'>PMC4620477][PMC3037319][PMC9441498[PMC3037319][PMC9441498]. It consists of two microRNAs, MIR615-5p and MIR615-3p [PMC4620477]. In OS patient tissues, MIR615 was significantly downregulated and associated with poor clinical outcomes [PMC9441498]. The gene's epigenetic regulation is a novel discovery, with its location in a high CpG density region suggesting potential epigenetic regulation mechanisms [PMC3037319]. Research involving CRISPR/Cas9 technology targeted the MIR615-3p-encoding region for gene editing to study its function in cancer cells [PMC4620477]. Overexpression of MIR615 has been shown to inhibit cell proliferation, migration, and invasion in vitro [PMC10057657]], indicating its potential role as a tumor suppressor. Additionally, changes in the expression of MIR615 have been observed in various studies involving miRNA-gene networks and miRNA expression profiles across different conditions [PMC5611503][PMC9702351][PMC5234833[PMC9702351][PMC5234833].

Literature search

29 open access papers mention hsa-mir-615
(246 sentences)

Sequence

8781 reads, 56 reads per million, 103 experiments

cucgggaggggcgggagGGGGGUCCCCGGUGCUCGGAUCucgagggugcuuauuguucggUCCGAGCCUGGGUCUCCCUCUUccccccaacccccc
...(((..(((.((((((((((..(((((.((((((((..((((.(.......).)))))))))))))))))...)))))))))))))..)))...

Structure

cuc   ag   c          -UC     U        Cu    g ug 
   ggg  ggg gggagGGGGG   CCCGG GCUCGGAU  cgag g  c
   |||  ||| ||||||||||   ||||| ||||||||  |||| |  u
   ccc  ccc cccUUCUCCC   GGGUC CGAGCCUg  gcuu u  u
ccc   aa   -          UCU     -        --    g ua 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr12: 54033950-54034045 [+]

Disease association

hsa-mir-615 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-615-5p

• Accession: MIMAT0004804
• Description: Homo sapiens hsa-miR-615-5p mature miRNA
• Sequence: 18 - GGGGGUCCCCGGUGCUCGGAUC - 39
• Evidence: experimental ; cloned [2]

Mature hsa-miR-615-3p

• Accession: MIMAT0003283
• Description: Homo sapiens hsa-miR-615-3p mature miRNA
• Sequence: 61 - UCCGAGCCUGGGUCUCCCUCUU - 82
• Evidence: experimental ; RT-PCR [1], SAGE [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692