Accession
MI0003599
Symbol
HGNC:
MIR589
Description
Homo sapiens
hsa-mir-589 precursor miRNA mir-589
Gene
family?
family?
RF00987;
mir-589
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR589 is a microRNA gene located within the fragile chromosomal region 7p22, which is susceptible to gaps and breaks in various cancers [PMC3634031]. This gene has been identified as differentially methylated and expressed in European American (EA) populations in the context of cancer [PMC8453167]. MIR589 is also among several microRNAs overexpressed in breast cancer (BC), suggesting its potential as a biomarker for diagnosis, prognosis, and therapeutic targets [PMC4508501]. Studies have shown that the expression of MIR589 decreases upon treatment with TGFβ1 in human peritoneal mesothelial cells (HPMCs), which has been observed in cells isolated from long-term peritoneal dialysis (PD) patients as well as HMrSV5 cells, with effects noted as early as 12 hours and persisting up to 48 hours [PMC3479401]. However, the role of MIR589 in mediating peritoneal fibrosis in vivo remains to be elucidated [PMC3479401]. Additionally, MIR589 was among the top 10 upregulated microRNAs following IFN-γ stimulation, indicating its responsiveness to inflammatory cytokines [PMC8010072], further emphasizing its potential relevance across various biological processes and disease states.
Literature search
15 open access papers mention hsa-mir-589
(37 sentences)
(37 sentences)
Sequence
5972
reads,
91
reads per million, 108 experiments
uccagccugugcccagcagccccUGAGAACCACGUCUGCUCUGAGcuggguacugccuguUCAGAACAAAUGCCGGUUCCCAGAcgcugccagcuggcc
.(((((.((......(((((..(((.(((((.(((.((.(((((((.((......)).))))))).)).)))..))))).)))..))))))))))))..
.(((((.((......(((((..(((.(((((.(((.((.(((((((.((......)).))))))).)).)))..))))).)))..))))))))))))..
Structure
-u c ugccca cc A -A C C u gu ccagc ug gcagc cUG GAACC CGU UG UCUGAGc gg a ||||| || ||||| ||| ||||| ||| || ||||||| || ggucg ac cgucg GAC CUUGG GUA AC AGACUug cc c cc - ------ cA C CC A A u gu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr7: 5495819-5495917 [-]
Disease association
hsa-mir-589 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-589-5p
| Accession | MIMAT0004799 |
| Description | Homo sapiens hsa-miR-589-5p mature miRNA |
| Sequence | 24 - UGAGAACCACGUCUGCUCUGAG - 45 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-589-3p
| Accession | MIMAT0003256 |
| Description | Homo sapiens hsa-miR-589-3p mature miRNA |
| Sequence | 61 - UCAGAACAAAUGCCGGUUCCCAGA - 84 |
| Evidence |
experimental
SAGE [1] |
| Database links |
|
| Predicted targets |
|
References
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