Stem-loop hsa-mir-582

Accession

MI0003589

Symbol

HGNC: MIR582

Description

Homo sapiens hsa-mir-582 precursor miRNA mir-582

Gene
family

RF00927; mir-582

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR582 is a microRNA (miRNA) that is notably upregulated in the CNFPA adenoma cluster, along with miR4774 and LINC01351, and is implicated in the regulation of various cellular pathways [PMC7652879]. This miRNA has been identified as a key player in enhancing epithelial-mesenchymal transition (EMT) by positively regulating the Wnt–β-catenin pathway, which is crucial for cancer progression [PMC7602903]. MIR582's role extends to maintaining cancer stem cell (CSC) stemness through activation of the WNT pathway, highlighting its potential as a therapeutic target for disrupting CSC regulatory networks [PMC9517164]. In non-small-cell lung cancer (NSCLC), MIR582 upregulation has been linked to increased expression of CSC-related genes and is associated with DNA copy number variations that suggest its overexpression may be tied to genetic alterations in lung cancer [PMC9517164; PMC4667703].'>PMC4667703].. The gene locus for MIR582 has been found to be frequently amplified across various lung cancer cell lines, further supporting its role in oncogenesis [PMC4667703].

Literature search

36 open access papers mention hsa-mir-582
(207 sentences)

Sequence

8076 reads, 523 reads per million, 124 experiments

aucugugcucuuugaUUACAGUUGUUCAACCAGUUACUaaucuaacuaauugUAACUGGUUGAACAACUGAACCcaaagggugcaaaguagaaacauu
...(((((((((((....(((((((((((((((((((..............)))))))))))))))))))....))))))))))).............

Structure

----------auc           aUUA                   Uaaucu 
             ugugcucuuug    CAGUUGUUCAACCAGUUAC      a
             |||||||||||    |||||||||||||||||||       
             acgugggaaac    GUCAACAAGUUGGUCAAUg      a
uuacaaagaugaa           CCAA                   uuaauc 

Annotation confidence High

Genome context

chr5: 59703606-59703703 [-]

Disease association

hsa-mir-582 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-582-5p

• Accession: MIMAT0003247
• Description: Homo sapiens hsa-miR-582-5p mature miRNA
• Sequence: 16 - UUACAGUUGUUCAACCAGUUACU - 38
• Evidence: experimental ; Microarray [1], RT-PCR [1], SAGE [1], cloned [2]

Mature hsa-miR-582-3p

• Accession: MIMAT0004797
• Description: Homo sapiens hsa-miR-582-3p mature miRNA
• Sequence: 53 - UAACUGGUUGAACAACUGAACC - 74
• Evidence: experimental ; cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692