Stem-loop hsa-mir-551b

Accession

MI0003575

Symbol

HGNC: MIR551B

Description

Homo sapiens hsa-mir-551b precursor miRNA mir-551

Gene
family

RF00892; mir-551

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR551B is a microRNA implicated in gene regulation, and its potential targets were investigated using computational tools [PMC6563032]. The analysis, employing algorithms like miRanda and Targetscan, suggested that MIR551B might interact with the 3′-UTR of the transcription factor ZEB1 [PMC6563032]. Furthermore, the possibility that MIR551B could also activate gene expression by acting on the promoters of certain genes was not ruled out [PMC6563032].

Literature search

20 open access papers mention hsa-mir-551b
(36 sentences)

Sequence

15819 reads, 204 reads per million, 64 experiments

agaugugcucuccuggcccauGAAAUCAAGCGUGGGUGAGACCuggugcagaacgggaagGCGACCCAUACUUGGUUUCAGaggcugugagaauaa
........((((.(((((..((((((((((.((((((....((((........))))......)))))).))))))))))..))))).))))....

Structure

agaugugc    c     ca          C      --GAGA    gug 
        ucuc uggcc  uGAAAUCAAG GUGGGU      CCug   c
        |||| |||||  |||||||||| ||||||      ||||    
        agag gucgg  ACUUUGGUUC UACCCA      gggc   a
----aaua    u     aG          A      GCGgaa    aag 

Annotation confidence High

Genome context

chr3: 168551854-168551949 [+]

Disease association

hsa-mir-551b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-551b-5p

• Accession: MIMAT0004794
• Description: Homo sapiens hsa-miR-551b-5p mature miRNA
• Sequence: 22 - GAAAUCAAGCGUGGGUGAGACC - 43
• Evidence: experimental ; cloned [2]

Mature hsa-miR-551b-3p

• Accession: MIMAT0003233
• Description: Homo sapiens hsa-miR-551b-3p mature miRNA
• Sequence: 61 - GCGACCCAUACUUGGUUUCAG - 81
• Evidence: experimental ; Microarray [1], RT-PCR [1], SAGE [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692