Accession
MI0003516
Symbol
HGNC:
MIR545
Description
Homo sapiens
hsa-mir-545 precursor miRNA mir-95
Gene
family?
family?
RF04053;
mir-95
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR545, identified as a pre-miRNA, has been observed to play a role in cell proliferation in colorectal cancer and is significantly upregulated in endometrial cancer [PMC7199595]. Despite its upregulation, no miRNA prediction binding site tool has confirmed a direct connection between MIR545 and GPR161, suggesting that while MIR545 may promote cell proliferation in UCEC, its effects likely involve additional factors [PMC7199595]. In cervical cancer (CC), MIR545 is targeted by circ_0067934, which acts as a sponge to downregulate its expression and is implicated in the progression of CC by inhibiting MIR545 and increasing EIF3C expression [PMC9260044]. Moreover, the overexpression of MIR545 has been linked to the inhibition of Ku70 activity in radioresistant Lewis Lung Carcinoma cell lines [PMC4453103] and is regulated by HBx [PMC9280728]. However, the statement that MIR545 directly targets RIG-I regulators in pancreatic ductal adenocarcinoma is not supported by the provided reference [PMC6370596]. Experiments using miRNA mimics have shown that a mimic for MIR545 produced no phenotype compared to control cells [PMC7801944], while estrogen-related receptor γ (ESRRG) has been identified as a potential target gene inversely related to the expression of MIR545 [PMC8789654].
Literature search
11 open access papers mention hsa-mir-545
(18 sentences)
(18 sentences)
Sequence
4665
reads,
223
reads per million, 57 experiments
cccagccuggcacauuaguaggccUCAGUAAAUGUUUAUUAGAUGAauaaaugaaugacucaUCAGCAAACAUUUAUUGUGUGCcugcuaaagugagcuccacagg
.....((((((((.((((((((((.((((((((((((.((.(((((.............))))))).)))))))))))).).))))))))).))).....).))))
.....((((((((.((((((((((.((((((((((((.((.(((((.............))))))).)))))))))))).).))))))))).))).....).))))
Structure
cccag - ----- a - U A A auaaa
ccug g cac uuaguaggc c CAGUAAAUGUUU UU GAUGA u
|||| | ||| ||||||||| | |||||||||||| || ||||| g
ggac c gug aaucgucCG G GUUAUUUACAAA GA CUacu a
----- a cucga a U U C - cagua
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chrX: 74287104-74287209 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-545
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-545 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-545-5p
| Accession | MIMAT0004785 |
| Description | Homo sapiens hsa-miR-545-5p mature miRNA |
| Sequence | 25 - UCAGUAAAUGUUUAUUAGAUGA - 46 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-545-3p
| Accession | MIMAT0003165 |
| Description | Homo sapiens hsa-miR-545-3p mature miRNA |
| Sequence | 63 - UCAGCAAACAUUUAUUGUGUGC - 84 |
| Evidence |
experimental
cloned [1-2] |
| Database links |
|
| Predicted targets |
|
References
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