miRBase entry: hsa-mir-539

Stem-loop hsa-mir-539

Accession

MI0003514

Symbol

HGNC: MIR539

Description

Homo sapiens hsa-mir-539 precursor miRNA

Literature search

27 open access papers mention hsa-mir-539
(87 sentences)

Sequence

4263 reads, 14 reads per million, 70 experiments

auacuugaGGAGAAAUUAUCCUUGGUGUGUucgcuuuauuuaugaugaAUCAUACAAGGACAAUUUCUUUuugaguau
(((((((((((((((((.((((((.(((((((((.........).)))).)))))))))).)))))))))))))))))

Structure

                 A      G    -    - uuu 
auacuugaGGAGAAAUU UCCUUG UGUG Uucg c   a
||||||||||||||||| |||||| |||| |||| |   u
uaugaguuUUUCUUUAA AGGAAC AUAC Aagu g   u
                 C      -    U    a uau

Annotation confidence High

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Genome context

chr14: 101047321-101047398 [+]

Clustered miRNAs

19 other miRNAs are < 10 kb from hsa-mir-539

Name	Accession	Chromosome	Start	End	Strand	Confidence

Disease association

hsa-mir-539 is associated with one or more human diseases in the Human microRNA Disease Database

Disease	Description	Category	PubMed ID

Database links

Mature hsa-miR-539-5p

Accession	MIMAT0003163
Description	Homo sapiens hsa-miR-539-5p mature miRNA
Sequence	9 - GGAGAAAUUAUCCUUGGUGUGU - 30
Evidence	experimental cloned [1,3], miRAP-cloned [2]

Mature hsa-miR-539-3p

Accession	MIMAT0022705
Description	Homo sapiens hsa-miR-539-3p mature miRNA
Sequence	49 - AUCAUACAAGGACAAUUUCUUU - 70
Evidence	not_experimental
Database links
Predicted targets

References

PubMed ID: 17604727
A mammalian microRNA expression atlas based on small RNA library sequencing
"Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
"Cell (2007) 129:1401-1414

PubMed ID: 16274478
Identification of clustered microRNAs using an ab initio prediction method
Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
BMC Bioinformatics (2005) 6:267

PubMed ID: 16973894
Mouse microRNA profiles determined with a new and sensitive cloning method
"Takada S, Berezikov E, Yamashita Y, Lagos-Quintana M, Kloosterman WP, Enomoto M, Hatanaka H, Fujiwara S, Watanabe H, Soda M, Choi YL, Plasterk RH, Cuppen E, Mano H"
"Nucleic Acids Res (2006) 34:e115