Accession
MI0003193
Symbol
HGNC:
MIR506
Description
Homo sapiens
hsa-mir-506 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR506, a noncoding RNA, is implicated in various biological processes and diseases, including primary biliary cholangitis (PBC), pancreatic ductal adenocarcinoma (PDAC), acute T-cell leukemia (TALL), and adrenocortical carcinoma (ACC) [PMC8147992; PMC9312874; PMC7477680;'>PMC7477680; PMC5764399].'>PMC5764399].. In PBC patients, MIR506 is upregulated in the intrahepatic bile ducts and influences the secretion of biliary epithelial cells by targeting AE2 [PMC8147992]. Although MIR506's interaction with miR124 is not a contributing factor to miR124T's effect on astrocytic cells [PMC5476465], its overexpression in Jurkat cells has been shown to regulate BCL2 gene expression, suggesting a role in apoptosis regulation [PMC7477680]. Additionally, low expression of MIR506 may lead to increased CDK6 and CTNNB1 mRNA levels in ACCs [PMC5764399], while its role extends to the modulation of reactive oxygen species in various cancers including lung cancer (LC) [PMC9442502]. The statement regarding MIR506 in wheat and its predicted target genes such as AB182944 has been removed due to lack of supporting evidence in the provided references.
Literature search
61 open access papers mention hsa-mir-506
(334 sentences)
(334 sentences)
Sequence
12157
reads,
403
reads per million, 25 experiments
gccaccaccaucagccauacuauguguagugccuUAUUCAGGAAGGUGUUACUUAAuagauuaauauuugUAAGGCACCCUUCUGAGUAGAguaaugugcaacauggacaacauuugugguggc
((((((((...........(((((((((.(((.((((((((((.(((((..((((.(((((....)))))))))))))).)))))))))).)))...))).)))))).........))))))))
((((((((...........(((((((((.(((.((((((((((.(((((..((((.(((((....)))))))))))))).)))))))))).)))...))).)))))).........))))))))
Structure
caucagccaua - --g c A UA A u
gccaccac cuaugu gua ugc uUAUUCAGGA GGUGU CUUA uagau a
|||||||| |||||| ||| ||| |||||||||| ||||| |||| |||||
cgguggug gguaca cgu aug GAUGAGUCUU CCACG GAAU guuua a
--uuuacaaca a gua A C -- - u
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 147230720-147230843 [-]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-506
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-506 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-506-3p
| Accession | MIMAT0002878 |
| Description | Homo sapiens hsa-miR-506-3p mature miRNA |
| Sequence | 71 - UAAGGCACCCUUCUGAGUAGA - 91 |
| Evidence |
experimental
array-cloned [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-506-5p
| Accession | MIMAT0022701 |
| Description | Homo sapiens hsa-miR-506-5p mature miRNA |
| Sequence | 35 - UAUUCAGGAAGGUGUUACUUAA - 56 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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