Accession
MI0003190
Symbol
HGNC:
MIR505
Description
Homo sapiens
hsa-mir-505 precursor miRNA mir-505
Gene
family?
family?
RF00781;
mir-505
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR505 is a microRNA that has been identified as a potential biomarker in various biological contexts and diseases [PMC9918015]. It is normalized to U6 and β-actin expression using the 2−ΔΔCT method [PMC6352865]. In the context of Parkinson's disease, MIR505 is significantly down-regulated in cerebrospinal fluid and brain tissue of patients [PMC6115491]. It has been observed to increase in the ovaries of females exposed to chlorpyrifos, suggesting a role in ovarian response to environmental toxins [PMC9918015]. MIR505 has also been proposed as a marker of ovarian aging, with its expression being induced while anti-Müllerian hormone (AMH) mRNA is reduced [PMC9918015]. In developmental biology, MIR505 can inhibit neural tube formation and cell growth through its interaction with various growth factors and signaling pathways [PMC7040864]. Its altered expression could be implicated in neural tube defects such as spina bifida, potentially through its interaction with SOX3 or independently by targeting specific genes involved in developmental pathways [PMC7040864]. Additionally, MIR505's expression can be modulated by factors such as cisplatin resistance via the Wnt/β-catenin pathway in cancer contexts [PMC9331520], and it has been identified upstream of genes like ATP11C, suggesting regulatory roles within intronic regions of other genes' transcripts [PMC4561498].
Literature search
33 open access papers mention hsa-mir-505
(194 sentences)
(194 sentences)
Sequence
22821
reads,
422
reads per million, 156 experiments
gaugcacccaguggGGGAGCCAGGAAGUAUUGAUGUuucugccaguuuagCGUCAACACUUGCUGGUUUCCUcucuggagcauc
(((((..((((.(((((((((((.((((.((((((((...........)))))))).)))).))))))))))).)))).)))))
(((((..((((.(((((((((((.((((.((((((((...........)))))))).)))).))))))))))).)))).)))))
Structure
ac u G A ucug
gaugc ccag ggGGGAGCCAG AAGU UUGAUGUu c
||||| |||| ||||||||||| |||| |||||||| c
cuacg gguc cUCCUUUGGUC UUCA AACUGCga a
-a u G C uuug
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chrX: 139924148-139924231 [-]
Disease association
hsa-mir-505 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-505-5p
| Accession | MIMAT0004776 |
| Description | Homo sapiens hsa-miR-505-5p mature miRNA |
| Sequence | 15 - GGGAGCCAGGAAGUAUUGAUGU - 36 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-505-3p
| Accession | MIMAT0002876 |
| Description | Homo sapiens hsa-miR-505-3p mature miRNA |
| Sequence | 51 - CGUCAACACUUGCUGGUUUCCU - 72 |
| Evidence |
experimental
array-cloned [1], cloned [2-3] |
| Database links |
|
| Predicted targets |
|
References
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