Stem-loop hsa-mir-501

Accession

MI0003185

Symbol

HGNC: MIR501

Description

Homo sapiens hsa-mir-501 precursor miRNA mir-500

Gene
family

RF01903; mir-500

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR501 is a microRNA (miRNA) that has been identified as one of the most elevated plasma miRNAs in community-acquired pneumonia (CAP) [PMC8358855]. While it is part of a novel miRNA family discovered in wheat, its association with schizophrenia is through single-nucleotide polymorphisms and protein-altering variants in the human host gene CLCN5, not the wheat gene [PMC5360763, PMC9390987].'>PMC9390987].. MIR501 is located on the X chromosome within the intronic region of the CLCN5 gene, and its major mature form, miR-501-3p, is highly expressed in various tissues and specific neuronal types [PMC9390987]. Studies using MIR501-knockout (KO) mice have demonstrated that its absence leads to reduced levels of mature mmu-miR-501-3p and mmu-miR-501-5p in the brain, without affecting nearby miRNAs [PMC9390987]. Conditional rescue experiments have indicated that miR-501-3p may play a role in modulating glutamatergic transmission, which could be significant for understanding the pathophysiology of schizophrenia [PMC9390987]. Due to the MIR501 locus's location on the X chromosome, male mice were used in experiments to circumvent the variability of X-chromosome inactivation that could complicate results in females [PMC9390987].

Literature search

35 open access papers mention hsa-mir-501
(59 sentences)

Sequence

9875 reads, 179 reads per million, 128 experiments

gcucuuccucucuAAUCCUUUGUCCCUGGGUGAGAgugcuuucugaaugcAAUGCACCCGGGCAAGGAUUCUgagagggugagc
((((.(((((((.(((((((.(.(((.(((((....(((.........)))...))))))))))))))))..))))))).))))

Structure

    u       -u       U U   U     AGAg   uuu 
gcuc uccucuc  AAUCCUU G CCC GGGUG    ugc   c
|||| |||||||  ||||||| | ||| |||||    |||   u
cgag gggagag  UUAGGAA C GGG CCCAC    Acg   g
    u       UC       - -   -     -GUA   uaa 

Annotation confidence High

Genome context

chrX: 50009722-50009805 [+]

Clustered miRNAs

7 other miRNAs are < 10 kb from hsa-mir-501

Disease association

hsa-mir-501 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-501-5p

• Accession: MIMAT0002872
• Description: Homo sapiens hsa-miR-501-5p mature miRNA
• Sequence: 14 - AAUCCUUUGUCCCUGGGUGAGA - 35
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-501-3p

• Accession: MIMAT0004774
• Description: Homo sapiens hsa-miR-501-3p mature miRNA
• Sequence: 51 - AAUGCACCCGGGCAAGGAUUCU - 72
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770