Accession
MI0003183
Symbol
HGNC:
MIR499A
Description
Homo sapiens
hsa-mir-499a precursor miRNA mir-499
Gene
family?
family?
RF00745;
mir-499
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR499A is a microRNA implicated in various cellular processes, and its expression and potential associations with diseases have been a subject of research [PMC4207808]. In a recent study, no significant correlation was found between the rs3746444 polymorphism of MIR499A and the expression levels of miR-499a [PMC8514969]. This suggests that this particular polymorphism may not play a role in regulating MIR499A expression or its functional consequences. Furthermore, the study investigated MIR499A expression in HepG2 cells, a human liver cancer cell line, following infection with either adenovirus expressing hepatitis B virus (Ad-HBV) or adenovirus expressing green fluorescent protein (Ad-GFP) [PMC4207808]. This was likely done to understand the impact of viral infection on MIR499A expression. Additionally, to elucidate the functional role of MIR499A in hepatocellular carcinoma (HCC), researchers identified and explored its target gene [PMC4207808]. The identification of target genes is crucial for understanding the molecular mechanisms through which microRNAs like MIR499A exert their effects on cellular functions and disease progression.
Literature search
136 open access papers mention hsa-mir-499a
(778 sentences)
(778 sentences)
Sequence
67990
reads,
1643
reads per million, 101 experiments
gcccuguccccugugccuugggcgggcggcugUUAAGACUUGCAGUGAUGUUUaacuccucuccacgugAACAUCACAGCAAGUCUGUGCUgcuucccgucccuacgcugccugggcagggu
(((((((((.....((...(((((((.(((.((..((((((((.((((((((((.............)))))))))).))))))))..)).))).)))).)))...)).....)))))))))
(((((((((.....((...(((((((.(((.((..((((((((.((((((((((.............)))))))))).))))))))..)).))).)))).)))...)).....)))))))))
Structure
ccugu cuu - c u UA A acucc
gcccugucc gc ggg cggg ggc gU AGACUUGC GUGAUGUUUa u
||||||||| || ||| |||| ||| || |||||||| |||||||||| c
ugggacggg cg ccc gccc ucg CG UCUGAACG CACUACAAgu u
uccgu cau u u U UG A gcacc
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr20: 34990376-34990497 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-499a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-499a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-499a-5p
| Accession | MIMAT0002870 |
| Description | Homo sapiens hsa-miR-499a-5p mature miRNA |
| Sequence | 33 - UUAAGACUUGCAGUGAUGUUU - 53 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-499a-3p
| Accession | MIMAT0004772 |
| Description | Homo sapiens hsa-miR-499a-3p mature miRNA |
| Sequence | 70 - AACAUCACAGCAAGUCUGUGCU - 91 |
| Evidence |
experimental
cloned [2] |
References
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