Accession
MI0003183
Symbol
HGNC:
MIR499A
Description
Homo sapiens
hsa-mir-499a precursor miRNA mir-499
Gene
family?
family?
RF00745;
mir-499
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
In our study, we failed to observe an association of the polymorphism in the rs3746444 polymorphism of MIR499A and the miR-499a expression [1]. MIR499A expression was also examined in Ad-HBV or Ad-GFP infected HepG2 cells [2]. In addition, we explored the target gene of MIR499A to disclose the underlying mechanism of MIR499A functions in HCC [2]. References: 1. Zhang, Y., Zhang, Y., Li, X., Zhang, X., Liang, H., Liang, W., ... & Wang, Y. (2021). The association between polymorphisms in microRNA genes and hepatocellular carcinoma risk: a meta-analysis. BMC cancer, 21(1), 1-12. [PMC8514969] 2. Wang, Y., Tohme, S., & Gao, Z. (2014). MicroRNA: a new therapeutic target for human hepatocellular carcinoma. Gastroenterology research and practice 2014. [PMC4207808]
Literature search
136 open access papers mention hsa-mir-499a
(778 sentences)
(778 sentences)
Sequence
67990
reads,
1643
reads per million, 101 experiments
gcccuguccccugugccuugggcgggcggcugUUAAGACUUGCAGUGAUGUUUaacuccucuccacgugAACAUCACAGCAAGUCUGUGCUgcuucccgucccuacgcugccugggcagggu
(((((((((.....((...(((((((.(((.((..((((((((.((((((((((.............)))))))))).))))))))..)).))).)))).)))...)).....)))))))))
(((((((((.....((...(((((((.(((.((..((((((((.((((((((((.............)))))))))).))))))))..)).))).)))).)))...)).....)))))))))
Structure
ccugu cuu - c u UA A acucc
gcccugucc gc ggg cggg ggc gU AGACUUGC GUGAUGUUUa u
||||||||| || ||| |||| ||| || |||||||| |||||||||| c
ugggacggg cg ccc gccc ucg CG UCUGAACG CACUACAAgu u
uccgu cau u u U UG A gcacc
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr20: 34990376-34990497 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-499a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-499a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-499a-5p
| Accession | MIMAT0002870 |
| Description | Homo sapiens hsa-miR-499a-5p mature miRNA |
| Sequence | 33 - UUAAGACUUGCAGUGAUGUUU - 53 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-499a-3p
| Accession | MIMAT0004772 |
| Description | Homo sapiens hsa-miR-499a-3p mature miRNA |
| Sequence | 70 - AACAUCACAGCAAGUCUGUGCU - 91 |
| Evidence |
experimental
cloned [2] |
References
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