Accession
MI0003165
Symbol
HGNC:
MIR517B
Description
Homo sapiens
hsa-mir-517b precursor miRNA mir-515
Gene
family?
family?
RF00639;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-517b is a microRNA isoform transcribed from the C19MC cluster and is implicated in various cellular processes, including cancer progression and differentiation [PMC8666996]. It has been associated with lower cancer stages and has a positive impact on patient survival, suggesting its potential role as a prognostic biomarker [PMC7648123]. The expression levels of hsa-mir-517b are linked with clinical stages I–III of cancer, indicating its involvement in the early stages of tumor development [PMC7499949]. Additionally, hsa-mir-517b is differentially expressed during sodium butyrate (NaB)-induced differentiation, highlighting its role in embryonic stem (ES) cell processes [PMC2581805]. Genetic variations such as the transition from allele G to allele A at rs1063053 can affect the binding site of hsa-mir-517b, which may have functional consequences on gene regulation [PMC5810033]. The expression of hsa-mir-517b has been quantitatively analyzed using specific microRNA assays to further understand its role in cellular functions [PMC3937405]. Moreover, this microRNA is involved in reducing pluripotency and contributing to chondrogenic processes, indicating its significance in stem cell differentiation and development [PMC6770352].
Literature search
20 open access papers mention hsa-mir-517b
(63 sentences)
(63 sentences)
Sequence
222
reads,
19
reads per million, 26 experiments
gugacCCUCUAGAUGGAAGCACUGUCUguugucuaagaaaagAUCGUGCAUCCCUUUAGAGUGUuac
(((((.(((((((.(((.((((.((((.............)))).)))).))).))))))).)))))
(((((.(((((((.(((.((((.((((.............)))).)))).))).))))))).)))))
Structure
C U A U guugu
gugac CUCUAGA GGA GCAC GUCU c
||||| ||||||| ||| |||| |||| u
cauUG GAGAUUU CCU CGUG UAga a
U C A C aaaga
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr19: 53721076-53721142 [+]
Clustered miRNAs
9 other miRNAs are < 10 kb from hsa-mir-517b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-517b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-517-5p
| Accession | MIMAT0002851 |
| Description | Homo sapiens hsa-miR-517-5p mature miRNA |
| Sequence | 6 - CCUCUAGAUGGAAGCACUGUCU - 27 |
| Evidence |
experimental
array-cloned [1] |
Mature hsa-miR-517b-3p
| Accession | MIMAT0002857 |
| Description | Homo sapiens hsa-miR-517b-3p mature miRNA |
| Sequence | 43 - AUCGUGCAUCCCUUUAGAGUGU - 64 |
| Evidence |
experimental
array-cloned [1] |
| Database links |
|
| Predicted targets |
|
References
|
