Accession
MI0003153
Symbol
HGNC:
MIR523
Description
Homo sapiens
hsa-mir-523 precursor miRNA mir-515
Gene
family?
family?
RF00639;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR523 is a microRNA gene that is part of the C19MC cluster on chromosome 19, which has implications in stem cell biology and tumorigenesis [PMC8508841]. In breast invasive carcinoma, the expression of MIR523 was not significantly different between carcinoma-associated anemia (CAA) and the control group with a variable threshold (P = .0718), but showed significance with a fixed threshold of 0.03 (P = .0443) [PMC7157974]. Additionally, MIR523 expression was nearly significant in another comparison within the same study (P = .0549) [PMC7157974]. MIR523 expression was also analyzed in an integrated dataset using the TCGA miRNA-seq dataset of liver hepatocellular carcinoma (LIHC) matched with the HCC-iCluster RNA-seq dataset [PMC7378193]. The statement regarding the prediction of targets for MIR523 and the relation to wheat EST sequences in databases is not supported by the provided reference [PMC2394755] and has been omitted from this summary.
Literature search
4 open access papers mention hsa-mir-523
(10 sentences)
(10 sentences)
Sequence
107
reads,
2
reads per million, 19 experiments
ucucaugcugugaccCUCUAGAGGGAAGCGCUUUCUGuugucugaaagaaaaGAACGCGCUUCCCUAUAGAGGGUuacccuuugaga
(((((....(((((((((((.((((((((((.((((....(((...)))..)))).)))))))))).)))))))))))....)))))
(((((....(((((((((((.((((((((((.((((....(((...)))..)))).)))))))))).)))))))))))....)))))
Structure
ugcu G U Guug g
ucuca gugaccCUCUA AGGGAAGCGC UUCU ucu
||||| ||||||||||| |||||||||| |||| ||| a
agagu cauUGGGAGAU UCCCUUCGCG AAGa aga
uucc A C --aa a
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr19: 53698385-53698471 [+]
Clustered miRNAs
10 other miRNAs are < 10 kb from hsa-mir-523
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-523 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-523-5p
| Accession | MIMAT0005449 |
| Description | Homo sapiens hsa-miR-523-5p mature miRNA |
| Sequence | 16 - CUCUAGAGGGAAGCGCUUUCUG - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-523-3p
| Accession | MIMAT0002840 |
| Description | Homo sapiens hsa-miR-523-3p mature miRNA |
| Sequence | 53 - GAACGCGCUUCCCUAUAGAGGGU - 75 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
References
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