Stem-loop hsa-mir-519c

Accession

MI0003148

Symbol

HGNC: MIR519C

Description

Homo sapiens hsa-mir-519c precursor miRNA mir-515

Gene
family

RF00639; mir-515

Literature search

27 open access papers mention hsa-mir-519c
(69 sentences)

Sequence

106 reads, 2 reads per million, 22 experiments

ucucagccugugaccCUCUAGAGGGAAGCGCUUUCUGuugucugaaagaaaagAAAGUGCAUCUUUUUAGAGGAUuacaguuugaga
((((((.((((((.((((((((((((.(((((((((....(((...)))..))))))))).)))))))))))).)))))).))))))

Structure

      c      c            A         Guug   g 
ucucag cuguga cCUCUAGAGGGA GCGCUUUCU    ucu  
|||||| |||||| |||||||||||| |||||||||    ||| a
agaguu gacauU GGAGAUUUUUCU CGUGAAAga    aga  
      u      A            A         --aa   a 

Annotation confidence High

Comments

The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor [2], leading to the -5p, -3p designations. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr19: 53686469-53686555 [+]

Clustered miRNAs

8 other miRNAs are < 10 kb from hsa-mir-519c

Disease association

hsa-mir-519c is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-519c-5p

• Accession: MIMAT0002831
• Description: Homo sapiens hsa-miR-519c-5p mature miRNA
• Sequence: 16 - CUCUAGAGGGAAGCGCUUUCUG - 37
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-519c-3p

• Accession: MIMAT0002832
• Description: Homo sapiens hsa-miR-519c-3p mature miRNA
• Sequence: 54 - AAAGUGCAUCUUUUUAGAGGAU - 75
• Evidence: experimental ; array-cloned [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770