Accession
MI0003146
Symbol
HGNC:
MIR520F
Description
Homo sapiens
hsa-mir-520f precursor miRNA mir-515
Gene
family?
family?
RF00639;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR520F is a microRNA gene that is part of the C19MC miRNA cluster, which includes a group of 46 miRNA genes [PMC7378193]. It has been identified in various studies involving different types of cancer and has been detected in the cerebrospinal fluid (CSF) of glioblastoma patients [PMC7014190]. The expression levels of MIR520F, along with other miRNAs, have been found to correlate with glioblastoma tissue biopsy samples and are associated with tumor volume, showing a 67% sensitivity and 80% specificity in distinguishing tumor presence [PMC9965735]. MIR520F is also part of a larger group of microRNAs detected in CSF samples that are being studied for their potential roles in cancer diagnostics [PMC8833415]. In breast invasive carcinoma research, cumulative expression data for the C19MC miRNA cluster, which includes MIR520F, has been processed to understand its role in cancer gene expression [PMC6193703]. However, MIR520F has also been identified as being downregulated in the villus tissue from women with recurrent pregnancy loss (RPL), suggesting its potential involvement beyond oncology and into reproductive health processes [PMC5572592].
Literature search
36 open access papers mention hsa-mir-520f
(189 sentences)
(189 sentences)
Sequence
252
reads,
22
reads per million, 8 experiments
ucucaggcugugacCCUCUAAAGGGAAGCGCUUUCUguggucagaaagaaaagcAAGUGCUUCCUUUUAGAGGGUUaccguuuggga
((((((((.((((((((((((((((((((((((((((....)))).........)))))))))))))))))))))))).))))))))
((((((((.((((((((((((((((((((((((((((....)))).........)))))))))))))))))))))))).))))))))
Structure
u --------- u
ucucaggc gugacCCUCUAAAGGGAAGCGCUU UCUg g
|||||||| |||||||||||||||||||||||| ||||
aggguuug caUUGGGAGAUUUUCCUUCGUGAA agac g
c cgaaaagaa u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr19: 53682159-53682245 [+]
Clustered miRNAs
8 other miRNAs are < 10 kb from hsa-mir-520f
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-520f is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-520f-3p
| Accession | MIMAT0002830 |
| Description | Homo sapiens hsa-miR-520f-3p mature miRNA |
| Sequence | 55 - AAGUGCUUCCUUUUAGAGGGUU - 76 |
| Evidence |
experimental
array-cloned [1], Illumina [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-520f-5p
| Accession | MIMAT0026609 |
| Description | Homo sapiens hsa-miR-520f-5p mature miRNA |
| Sequence | 15 - CCUCUAAAGGGAAGCGCUUUCU - 36 |
| Evidence |
experimental
Illumina [2] |
References
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