Accession
MI0003138
Symbol
HGNC:
MIR497
Description
Homo sapiens
hsa-mir-497 precursor miRNA mir-497
Gene
family?
family?
RF00793;
mir-497
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR497 is a microRNA implicated in the regulation of neuronal death post-ischemia, as demonstrated in previous research [PMC4998122]. The current study marks the first instance of establishing a link between MIR497 and the neuronal damage that occurs as a result of seizures [PMC4998122]. Additionally, MIR497 has been associated with the modulation of lung cancer cells' resistance to cisplatin, a chemotherapy drug, through a mechanism that involves AKT2 [PMC8787930]. Furthermore, it has been reported that LINC00152 can act as a molecular sponge for MIR497, thereby serving as its negative regulator and influencing its activity within cells [PMC7011539].
Literature search
117 open access papers mention hsa-mir-497
(1034 sentences)
(1034 sentences)
Sequence
37583
reads,
380
reads per million, 124 experiments
ccaccccgguccugcucccgcccCAGCAGCACACUGUGGUUUGUacggcacuguggccacgucCAAACCACACUGUGGUGUUAGAgcgagggugggggaggcaccgccgagg
...((.(((((((.((((((((((((((.((((.(((((((((.(((((......)))..)).))))))))).)))).)))).....).))))))))))))....)))).))
...((.(((((((.((((((((((((((.((((.(((((((((.(((((......)))..)).))))))))).)))).)))).....).))))))))))))....)))).))
Structure
cca c ---- g - ----- G C U -- ac cc cggu ccu cucccgccc C AGCA CACA UGUGGUUUG ac ggc u || |||| ||| ||||||||| | |||| |||| ||||||||| || ||| gg gccg gga ggggguggg g UUGU GUGU ACACCAAAC ug ccg g --- a ccac - a cgAGA G C c ca gu
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr17: 7017911-7018022 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-497
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-497 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-497-5p
| Accession | MIMAT0002820 |
| Description | Homo sapiens hsa-miR-497-5p mature miRNA |
| Sequence | 24 - CAGCAGCACACUGUGGUUUGU - 44 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-497-3p
| Accession | MIMAT0004768 |
| Description | Homo sapiens hsa-miR-497-3p mature miRNA |
| Sequence | 64 - CAAACCACACUGUGGUGUUAGA - 85 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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