Stem-loop hsa-mir-193b

Accession

MI0003137

Symbol

HGNC: MIR193B

Description

Homo sapiens hsa-mir-193b precursor miRNA mir-193

Gene
family

RF01895; mir-193

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR193B is identified as a tumor suppressor in the hematopoietic system, with a significant role in the regulation of cell cycle and apoptosis in Acute Myelocytic Leukemia (AML) [PMC7273449]. It has been shown to induce apoptosis and cause G1/S-phase cell cycle arrest across various AML subtypes, suggesting its potential as a therapeutic target [PMC7273449]. The genetic locus of MIR193B is within the MIR193B host gene (MIR193BHG) on chromosome 16 of the human genome, as per the GRCh38/hg38 assembly available on the UCSC Genome Browser [PMC9779864]. This locus is also characterized by its high sequence conservation across different species, indicating its evolutionary importance and potential functional significance [PMC9779864].

Literature search

160 open access papers mention hsa-mir-193b
(415 sentences)

Sequence

114169 reads, 606 reads per million, 134 experiments

guggucucagaauCGGGGUUUUGAGGGCGAGAUGAguuuauguuuuauccAACUGGCCCUCAAAGUCCCGCUuuuggggucau
((((((((((((.(((((((((((((((.((.((.((.........)).)).)).))))))))))))))).))))))))))))

Structure

            u               G  A  A  uua 
guggucucagaa CGGGGUUUUGAGGGC AG UG gu   u
|||||||||||| ||||||||||||||| || || ||   g
uacugggguuuU GCCCUGAAACUCCCG UC Ac ua   u
            C               G  A  c  uuu 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr16: 14303967-14304049 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-193b

Disease association

hsa-mir-193b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-193b-5p

• Accession: MIMAT0004767
• Description: Homo sapiens hsa-miR-193b-5p mature miRNA
• Sequence: 14 - CGGGGUUUUGAGGGCGAGAUGA - 35
• Evidence: experimental ; cloned [3-4]

Mature hsa-miR-193b-3p

• Accession: MIMAT0002819
• Description: Homo sapiens hsa-miR-193b-3p mature miRNA
• Sequence: 51 - AACUGGCCCUCAAAGUCCCGCU - 72
• Evidence: experimental ; array-cloned [1], cloned [2-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267