Accession
MI0003132
Symbol
HGNC:
MIR493
Description
Homo sapiens
hsa-mir-493 precursor miRNA mir-493
Gene
family?
family?
RF04100;
mir-493
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR493 is a microRNA that has been identified as down-regulated in bladder cancer (BC) [PMC3828615], yet paradoxically, it is also reported as upregulated in various cancers [PMC9775527]. This microRNA has been implicated in significant biological processes, as the knockout of its target gene, Pcgf2, along with the targets of other miRNAs, has been associated with prenatal and postnatal growth retardation and lethality [PMC5886287]. Furthermore, MIR493 is considered one of the most influential miRNAs due to the severe defects observed upon deletion of its target genes [PMC5886287]. However, the statement that mutations in CNTN1 and SCNN1B, which are targets of MIR493, are linked to a phenotype resembling Temple syndrome is not supported by the provided reference [PMC5886287]. In a study confirming sequencing results related to the DLK1-DIO3 genomic region, MIR493 was one of four representative miRNAs selected for analysis [PMC7308478]. Additionally, MIR493 was among the most differentially expressed (DE) miRNAs identified in a genomic region associated with certain phenotypes in dogs according to an analysis comparing affected versus control groups [PMC8376273].
Literature search
36 open access papers mention hsa-mir-493
(272 sentences)
(272 sentences)
Sequence
5046
reads,
96
reads per million, 85 experiments
cuggccuccagggcuUUGUACAUGGUAGGCUUUCAUUcauucguuugcacauucggUGAAGGUCUACUGUGUGCCAGGcccugugccag
(((((...((((((((.((((((((((((((((((((.................)))))))))))))))))))).)))))))).)))))
(((((...((((((((.((((((((((((((((((((.................)))))))))))))))))))).)))))))).)))))
Structure
cuc U cauucgu
cuggc cagggcuU GUACAUGGUAGGCUUUCAUU u
||||| |||||||| |||||||||||||||||||| u
gaccg gucccGGA CGUGUGUCAUCUGGAAGUgg g
--u C cuuacac
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature miRNA sequences were named miR-493-5p and miR-493-3p in [1,2] and here. Landgraf et al. showed that the 3' product is the predominant one [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr14: 100869060-100869148 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-493
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-493 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-493-5p
| Accession | MIMAT0002813 |
| Description | Homo sapiens hsa-miR-493-5p mature miRNA |
| Sequence | 16 - UUGUACAUGGUAGGCUUUCAUU - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-493-3p
| Accession | MIMAT0003161 |
| Description | Homo sapiens hsa-miR-493-3p mature miRNA |
| Sequence | 57 - UGAAGGUCUACUGUGUGCCAGG - 78 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
References
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