Stem-loop hsa-mir-488

Accession

MI0003123

Symbol

HGNC: MIR488

Description

Homo sapiens hsa-mir-488 precursor miRNA mir-488

Gene
family

RF00861; mir-488

Literature search

28 open access papers mention hsa-mir-488
(167 sentences)

Sequence

607 reads, 56 reads per million, 56 experiments

gagaaucaucucuCCCAGAUAAUGGCACUCUCAAacaaguuuccaaauuguUUGAAAGGCUAUUUCUUGGUCagaugacucuc
((((.((((((..((.(((.((((((.((.((((((((.........)))))))).))))))))))).))..)))))).))))

Structure

    a      cu  C   U      A  C        guu 
gaga ucaucu  CC AGA AAUGGC CU UCAAacaa   u
|||| ||||||  || ||| |||||| || ||||||||   c
cucu aguaga  GG UCU UUAUCG GA AGUUuguu   c
    c      CU  U   -      -  A        aaa 

Annotation confidence High

Comments

miR-488-3p cloned in [2] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.

Genome context

chr1: 177029363-177029445 [-]

Disease association

hsa-mir-488 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-488-5p

• Accession: MIMAT0002804
• Description: Homo sapiens hsa-miR-488-5p mature miRNA
• Sequence: 14 - CCCAGAUAAUGGCACUCUCAA - 34
• Evidence: experimental ; array-cloned [1]

Mature hsa-miR-488-3p

• Accession: MIMAT0004763
• Description: Homo sapiens hsa-miR-488-3p mature miRNA
• Sequence: 52 - UUGAAAGGCUAUUUCUUGGUC - 72
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770